The burden of malaria mortality among African children in the year 2000.
The burden of malaria mortality among African children in the year 2000.
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DOI：
10.1093/ije/dyl027
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发表时间：
2006-06
影响因子：
7.7
通讯作者：
Steketee RW
中科院分区：
文献类型：
--
作者：
Rowe AK;Rowe SY;Snow RW;Korenromp EL;Schellenberg JR;Stein C;Nahlen BL;Bryce J;Black RE;Steketee RW
虽然疟疾是造成儿童死亡的主要原因，但关于其直接和间接负担的有据可查的估计数很少。我们的目标是估计2000年撒哈拉以南非洲5岁以下儿童直接死于疟疾的人数。我们将人口分为六个亚群，并使用文献综述中确定的研究结果，估计每个亚群的疟疾死亡率。疟疾死亡人数是通过将每个亚群乘以其相应的发病率来估算的。进行敏感度分析以评估不同关键假设的影响。文献综述确定了来自中部非洲14个国家的31项研究以及来自南部非洲4个国家的17项研究和报告。2000年，我们估计约有1亿儿童生活在发生疟疾传播的地区，803 620名儿童（精确估计数：705 821-901 418）死于疟疾的直接影响。在撒哈拉以南非洲，包括未感染疟疾的人口，疟疾占儿童死亡的18.0%（精确估计：15.8%-20.2%）。这些估计数对关于不明原因死亡原因的极端假设很敏感。根据现有最佳数据和方法得出的这些估计数清楚地表明疟疾造成的巨大死亡负担。我们强调，这些估计数是有许多局限性的近似值，没有考虑到疟疾造成的巨大间接负担。我们描述的信息需求，如果填补，可能会提高未来估计的有效性。
Although malaria is a leading cause of child deaths, few well-documented estimates of its direct and indirect burden exist. Our objective was to estimate the number of deaths directly attributable to malaria among children <5 years old in sub-Saharan Africa for the year 2000. We divided the population into six sub-populations and, using results of studies identified in a literature review, estimated a malaria mortality rate for each sub-population. Malaria deaths were estimated by multiplying each sub-population by its corresponding rate. Sensitivity analyses were performed to assess the impact of varying key assumptions. The literature review identified 31 studies from 14 countries in middle Africa and 17 studies and reports from four countries in southern Africa. In 2000, we estimated that ~100 million children lived in areas where malaria transmission occurs and that 803 620 (precision estimate: 705 821–901 418) children died from the direct effects of malaria. For all of sub-Saharan Africa, including populations not exposed to malaria, malaria accounted for 18.0% (precision estimate: 15.8–20.2%) of child deaths. These estimates were sensitive to extreme assumptions about the causes of deaths with no known cause. These estimates, based on the best available data and methods, clearly demonstrate malaria’s enormous mortality burden. We emphasize that these estimates are an approximation with many limitations and that the estimates do not account for malaria’s large indirect burden. We describe information needs that, if filled, might improve the validity of future estimates.
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DOI：
10.1016/0035-9203(94)90391-3
发表时间：
1994-07-01
影响因子：
2.2
作者：
BINKA, FN;MORRIS, SS;ARYEETEY, ME
通讯作者：
ARYEETEY, ME
影响因子：
168.9
作者：
ALONSO, PL;LINDSAY, SW;GREENWOOD, BM
通讯作者：
GREENWOOD, BM
DOI：
10.1016/0035-9203(93)90170-u
发表时间：
1993-06-01
影响因子：
2.2
作者：
ALONSO, PL;LINDSAY, SW;GREENWOOD, BM
通讯作者：
GREENWOOD, BM
影响因子：
7.7
作者：
Chandramohan, D;Setel, P;Quigley, M
通讯作者：
Quigley, M
影响因子：
2.7
作者：
Charlwood, JD;Qassim, M;Smith, T
通讯作者：
Smith, T