Nutritional regulation of oligodendrocyte differentiation regulates perineuronal net remodeling in the median eminence.
Nutritional regulation of oligodendrocyte differentiation regulates perineuronal net remodeling in the median eminence.
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DOI：
10.1016/j.celrep.2021.109362
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发表时间：
2021-07-13
期刊：
影响因子：
8.8
通讯作者：
Blouet C
中科院分区：
文献类型：
--
作者：
Kohnke S;Buller S;Nuzzaci D;Ridley K;Lam B;Pivonkova H;Bentsen MA;Alonge KM;Zhao C;Tadross J;Holmqvist S;Shimizu T;Hathaway H;Li H;Macklin W;Schwartz MW;Richardson WD;Yeo GSH;Franklin RJM;Karadottir RT;Rowitch DH;Blouet C
下丘脑内侧基底核（MBH;下丘脑弓状核[ARH]和正中隆起[ME]）是产生维持能量平衡所需的复杂稳态反馈反应的关键营养感受部位。在这里，我们表明，重新喂养后，一夜快速触发少突胶质细胞祖细胞的增殖和分化，导致新的少突胶质细胞的生产在ME具体。在这种营养模式中，ME神经元束膜网（PNNs），ARH代谢功能的新兴调节因子，被迅速重塑，这一过程需要少突胶质细胞祖细胞中的髓鞘调节因子（Myrf）。在遗传性肥胖ob/ob小鼠中，ME少突胶质细胞分化和PNN重塑的营养调节被钝化，并且局部PNN的酶消化增加食物摄入和体重增加。我们的结论是MBH PNNs需要在瘦小鼠的能量平衡的维护和重塑在成年ME的少突胶质细胞分化的营养控制。正中隆起含有密集的新形成的少突胶质细胞营养信号调节正中隆起中的少突胶质细胞分化正中隆起中的少突胶质细胞可塑性调节局部神经元周网Kohnke et al.发现正中隆起少突胶质细胞的增殖和分化对营养信号有独特的反应，揭示了这种细胞类型的可塑性。他们直接牵连成人出生的少突胶质细胞在当地的神经元周围网络的调节，并表明这些细胞外结构调节能量平衡的控制。
The mediobasal hypothalamus (MBH; arcuate nucleus of the hypothalamus [ARH] and median eminence [ME]) is a key nutrient sensing site for the production of the complex homeostatic feedback responses required for the maintenance of energy balance. Here, we show that refeeding after an overnight fast rapidly triggers proliferation and differentiation of oligodendrocyte progenitors, leading to the production of new oligodendrocytes in the ME specifically. During this nutritional paradigm, ME perineuronal nets (PNNs), emerging regulators of ARH metabolic functions, are rapidly remodeled, and this process requires myelin regulatory factor (Myrf) in oligodendrocyte progenitors. In genetically obese ob/ob mice, nutritional regulations of ME oligodendrocyte differentiation and PNN remodeling are blunted, and enzymatic digestion of local PNN increases food intake and weight gain. We conclude that MBH PNNs are required for the maintenance of energy balance in lean mice and are remodeled in the adult ME by the nutritional control of oligodendrocyte differentiation. The median eminence contains a dense population of newly formed oligodendrocytes Nutritional signals regulate oligodendrocyte differentiation in the median eminence Oligodendrocyte plasticity in the median eminence regulates local perineuronal nets Kohnke et al. find that median eminence oligodendrocyte proliferation and differentiation uniquely respond to nutritional signals, revealing the plasticity of this cell type. They directly implicate adult-born oligodendrocytes in the regulation of local perineuronal nets,and show that these extracellular structures modulate the control of energy balance.
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影响因子：
17.1
作者：
Fard MK;van der Meer F;Sánchez P;Cantuti-Castelvetri L;Mandad S;Jäkel S;Fornasiero EF;Schmitt S;Ehrlich M;Starost L;Kuhlmann T;Sergiou C;Schultz V;Wrzos C;Brück W;Urlaub H;Dimou L;Stadelmann C;Simons M
通讯作者：
Simons M
影响因子：
25
作者：
Hughes EG;Orthmann-Murphy JL;Langseth AJ;Bergles DE
通讯作者：
Bergles DE
影响因子：
9.8
作者：
Laitman BM;Asp L;Mariani JN;Zhang J;Liu J;Sawai S;Chapouly C;Horng S;Kramer EG;Mitiku N;Loo H;Burlant N;Pedre X;Hara Y;Nudelman G;Zaslavsky E;Lee YM;Braun DA;Lu QR;Narla G;Raine CS;Friedman SL;Casaccia P;John GR
通讯作者：
John GR
影响因子：
6.2
作者：
Bottelbergs, Astrid;Verheijden, Simon;Baes, Myriam
通讯作者：
Baes, Myriam
DOI：
10.1016/j.mcn.2012.03.007
发表时间：
2012-05
期刊：
Molecular and cellular neurosciences
影响因子：
--
作者：
Dugas JC;Ibrahim A;Barres BA
通讯作者：
Barres BA