Chick midgut morphogenesis.

Chick midgut morphogenesis.
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雏鸡中肠形态发生。

DOI:
10.1387/ijdb.170325ct
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发表时间:
2018
期刊:
The International journal of developmental biology
影响因子:
--
通讯作者:
Tabin CJ
Tabin CJ
中科院分区:
其他
文献类型:
--
作者:
Huycke TR;Tabin CJ

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胃肠道是营养吸收所必需的器官系统。作为早期发育的一根简单的管子,原始的肠道沿着其前后轴被划分为不同的隔室,这些隔间具有独特的形态,与它们在消化过程中的功能有关。这些形态是通过发育逐渐获得的,因为肠道是由组织相互作用形成的,本质上是分子和机械的,涉及所有三个胚层。以中肠形态发生为重点,我们回顾了在鸡胚胎中的工作,展示了这些分子信号和机械力如何将发育中的肠管塑造成成熟的形式。特别是,我们强调了中肠增加其吸收表面积的两种机制:环状和绒毛。此外,我们回顾了肠中胚层的分化和分化为机械驱动蠕动和恶化过程本身的平滑肌层的模式。在相关的情况下,我们在其他模型系统的实验数据的背景下讨论了鸡中肠形态发生的机制。
The gastrointestinal tract is an essential system of organs required for nutrient absorption. As a simple tube early in development, the primitive gut is patterned along its anterior-posterior axis into discrete compartments with unique morphologies relevant to their functions in the digestive process. These morphologies are acquired gradually through development as the gut is patterned by tissue interactions, both molecular and mechanical in nature, involving all three germ layers. With a focus on midgut morphogenesis, we review work in the chick embryo demonstrating how these molecular signals and mechanical forces sculpt the developing gut tube into its mature form. In particular, we highlight two mechanisms by which the midgut increases its absorptive surface area: looping and villification. Additionally, we review the differentiation and patterning of the intestinal mesoderm into the layers of smooth muscle that mechanically drive peristalsis and the villification process itself. Where relevant, we discuss the mechanisms of chick midgut morphogenesis in the context of experimental data from other model systems.
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