The chirality of gut rotation derives from left-right asymmetric changes in the architecture of the dorsal mesentery.
The chirality of gut rotation derives from left-right asymmetric changes in the architecture of the dorsal mesentery.
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肠道旋转的手性源自背肠肠结构的左右不对称变化。
DOI：
10.1016/j.devcel.2008.05.001
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发表时间：
2008-07
影响因子：
11.8
通讯作者：
Tabin, Clifford J.
中科院分区：
文献类型：
--
作者：
Davis, Nicole M.;Kurpios, Natasza A.;Sun, Xiaoxia;Gros, Jerome;Martin, James F.;Tabin, Clifford J.
我们已经调查的结构基础，其中的逆时针方向的肠是成立的。中肠循环的手性是由背肠系膜细胞结构的左右不对称决定的，背肠系膜是连接原肠管和体壁的结构。背侧肠系膜的间充质细胞在左侧比右侧更密集，此外，左侧上覆的上皮表现出柱状形态，与右侧的立方形形态相反。这些特性由一组转录因子指示：Pitx 2和Isl 1特异性表达在左侧，Tbx 18表达在右侧，调节分泌蛋白Nodal的下游，Nodal仅存在于左侧。细胞组织的差异导致肠系膜呈梯形，使原肠管倾斜。
We have investigated the structural basis by which the counter-clockwise direction of the amniote gut is established. The chirality of midgut looping is determined by left-right asymmetries in the cellular architecture of the dorsal mesentery, the structure that connects the primitive gut tube to the body wall. The mesenchymal cells of the dorsal mesentery are more condensed on the left side than on the right and, additionally, the overlying epithelium on the left side exhibits a columnar morphology, in contrast to a cuboidal morphology on the right. These properties are instructed by a set of transcription factors: Pitx2 and Isl1 specifically expressed on the left side, and Tbx18 expressed on the right, regulated downstream of the secreted protein Nodal which is present exclusively on the left side. The resultant differences in cellular organization cause the mesentery to assume a trapezoidal shape, tilting the primitive gut tube leftward.
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影响因子：
56.9
作者：
Horne-Badovinac, S;Rebagliati, M;Stainier, DYR
通讯作者：
Stainier, DYR
影响因子：
64.8
作者：
Ryan, AK;Blumberg, B;Belmonte, JCI
通讯作者：
Belmonte, JCI
影响因子：
30.8
作者：
Bamforth, SD;Bragança, J;Bhattacharya, S
通讯作者：
Bhattacharya, S
影响因子：
2.4
作者：
Haenig, B;Kispert, A
通讯作者：
Kispert, A
影响因子：
9.2
作者：
Horne-Badovinac, S;Lin, D;Abdelilah-Seyfried, S
通讯作者：
Abdelilah-Seyfried, S