IL-1beta processing in host defense: beyond the inflammasomes.
IL-1beta processing in host defense: beyond the inflammasomes.
复制标题
DOI：
10.1371/journal.ppat.1000661
复制
发表时间：
2010-02-26
期刊：
影响因子：
6.7
通讯作者：
Joosten LA
中科院分区：
文献类型：
--
作者：
Netea MG;Simon A;van de Veerdonk F;Kullberg BJ;Van der Meer JW;Joosten LA
刺激和释放促炎细胞因子是激活有效的天然宿主防御，进而调节适应性免疫反应的关键步骤。白介素1β(IL-1β)和IL-18是重要的促炎细胞因子，一方面激活单核细胞、巨噬细胞和中性粒细胞，另一方面诱导Th1和Th17适应性细胞反应。它们以非活性前体的形式分泌，前-IL-1β和前-IL-18的加工依赖于蛋白酶的切割。其中最重要的酶之一是caspase-1，它又被称为炎症体的几个蛋白质平台激活。炎症体的激活在不同的细胞类型中是不同的，caspase-1或炎症体成分缺陷的基因敲除小鼠对几种类型的感染的易感性增加。然而，在其他感染和无菌炎症模型中，caspase-1似乎不那么重要，替代机制如中性粒细胞衍生的丝氨酸蛋白酶或微生物病原体释放的蛋白酶可以处理和激活IL-1β。总之，IL-1β/IL-18在感染过程中的处理是一个复杂的过程，其中炎性小体只是几种激活机制中的一种。
Stimulation and release of proinflammatory cytokines is an essential step for the activation of an effective innate host defense, and subsequently for the modulation of adaptive immune responses. Interleukin-1β (IL-1β) and IL-18 are important proinflammatory cytokines that on the one hand activate monocytes, macropages, and neutrophils, and on the other hand induce Th1 and Th17 adaptive cellular responses. They are secreted as inactive precursors, and the processing of pro-IL-1β and pro-IL-18 depends on cleavage by proteases. One of the most important of these enzymes is caspase-1, which in turn is activated by several protein platforms called the inflammasomes. Inflammasome activation differs in various cell types, and knock-out mice defective in either caspase-1 or inflammasome components have an increased susceptibility to several types of infections. However, in other infections and in models of sterile inflammation, caspase-1 seems to be less important, and alternative mechanisms such as neutrophil-derived serine proteases or proteases released from microbial pathogens can process and activate IL-1β. In conclusion, IL-1β/IL-18 processing during infection is a complex process in which the inflammasomes are only one of several activation mechanisms.
登录
查看更多内容
影响因子：
4.4
作者：
Bellocchio, S;Montagnoli, C;Romani, L
通讯作者：
Romani, L
影响因子：
5.4
作者：
Franchi, Luigi;Stoolman, Joshua;Nunez, Gabriel
通讯作者：
Nunez, Gabriel
影响因子：
5.5
作者：
Fantuzzi, G;Dinarello, CA
通讯作者：
Dinarello, CA
影响因子：
56.9
作者：
Dostert, Catherine;Petrilli, Virginie;Tschopp, Jurg
通讯作者：
Tschopp, Jurg
DOI：
10.4049/jimmunol.0901363
发表时间：
2009-07-15
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Bauernfeind FG;Horvath G;Stutz A;Alnemri ES;MacDonald K;Speert D;Fernandes-Alnemri T;Wu J;Monks BG;Fitzgerald KA;Hornung V;Latz E
通讯作者：
Latz E