Controlling Human Rabies: The Development of an Effective, Inexpensive and Locally Made Passive Cooling Device for Storing Thermotolerant Animal Rabies Vaccines.
Controlling Human Rabies: The Development of an Effective, Inexpensive and Locally Made Passive Cooling Device for Storing Thermotolerant Animal Rabies Vaccines.
复制标题
DOI：
10.3390/tropicalmed5030130
复制
发表时间：
2020-08-11
影响因子：
2.9
通讯作者：
Lankester F
中科院分区：
文献类型：
--
作者：
Lugelo A;Hampson K;Bigambo M;Kazwala R;Lankester F
耐热疫苗极大地提高了大规模疫苗接种计划的范围和影响，以消除天花、脊髓灰质炎和牛瘟等疾病。最近的一项研究表明，Nobivac® 犬狂犬病疫苗的效力在 30°C 下实验储存三个月后并未受到影响。我们进行了一项研究，开发一种被动冷却装置（PCD），可以在波动的低于环境温度下储存耐热疫苗。通过坦桑尼亚北部当地社区的参与过程，我们为当地制造开发了创新的 PCD 设计。然后进行了一系列现场实验，以评估五种 PCD 在不同气候条件下储存疫苗的有效性。经过迭代改进，最终的原型“Zeepot Clay”以每台 11 美元的成本开发出来。在为期 12 个月的进一步现场测试阶段，尽管环境温度超过 42 °C，但设备的内部温度仍保持在 26 °C 以下。因此，我们的研究表明，本地设计的 PCD 可用于在低于环境温度下储存耐热狂犬病疫苗。这些结果可用于扩大中低收入国家的大规模狗疫苗接种计划，特别是对于电力和冷链疫苗储存有限的难以接触的人群。
Thermotolerant vaccines greatly improved the reach and impact of large-scale vaccination programs to eliminate diseases such as smallpox, polio and rinderpest. A recent study demonstrated that the potency of the Nobivac® Canine Rabies vaccine was not impacted following experimental storage at 30 °C for three months. We conducted a study to develop a passive cooling device (PCD) that could store thermotolerant vaccines under fluctuating subambient temperatures. Through a participatory process with local communities in Northern Tanzania, we developed innovative PCD designs for local manufacture. A series of field experiments were then carried out to evaluate the effectiveness of five PCDs for vaccine storage under varying climatic conditions. Following iterative improvement, a final prototype “Zeepot Clay” was developed at the cost of US$11 per unit. During a further field-testing phase over a 12-month period, the internal temperature of the device remained below 26 °C, despite ambient temperatures exceeding 42 °C. Our study thus demonstrated that locally designed PCDs have utility for storing thermotolerant rabies vaccines at subambient temperatures. These results have application for the scaling up of mass dog vaccination programs in low-and-middle income countries, particularly for hard-to-reach populations with limited access to power and cold-chain vaccine storage.
登录
查看更多内容
影响因子：
11.1
作者：
Ozawa S;Clark S;Portnoy A;Grewal S;Stack ML;Sinha A;Mirelman A;Franklin H;Friberg IK;Tam Y;Walker N;Clark A;Ferrari M;Suraratdecha C;Sweet S;Goldie SJ;Garske T;Li M;Hansen PM;Johnson HL;Walker D
通讯作者：
Walker D
影响因子：
8.7
作者：
Dawoud, Belal
通讯作者：
Dawoud, Belal
影响因子：
4.8
作者：
Chen, Sheng-I;Norman, Bryan A.;Lee, Bruce Y.
通讯作者：
Lee, Bruce Y.
影响因子：
0.5
作者：
Olsen, Philippa;Elliott, Edward
通讯作者：
Elliott, Edward
影响因子：
3.2
作者：
Nguyen JL;Dockery DW
通讯作者：
Dockery DW