Steroid hormone regulation of innate immunity in Drosophila melanogaster.
Steroid hormone regulation of innate immunity in Drosophila melanogaster.
复制标题
类固醇激素对黑腹果蝇先天免疫的调节。
DOI：
10.1371/journal.pgen.1010782
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发表时间：
2023-06
期刊：
影响因子：
4.5
通讯作者：
中科院分区：
文献类型：
--
作者：
内分泌信号网络控制后生动物不同的生物过程和生活史特征。在无脊椎动物和脊椎动物中，类固醇激素调节免疫系统的功能，以响应内在和环境刺激，如微生物感染。这种内分泌免疫调节的机制是复杂的，并构成了一项由遗传易驯化的动物模型促进的持续研究努力。20-羟基蜕皮酮(20E)是节肢动物中的主要类固醇激素，主要研究其在调节发育过渡和变态过程中的重要作用；20E还调节多种昆虫的天然免疫。本文就20E介导的先天免疫反应的研究现状作一综述。在一系列全变态昆虫中总结了20E驱动的发育转变和先天免疫激活之间的相关性的流行。随后的讨论集中在利用果蝇现有的广泛遗传资源进行的研究上，这些研究已经开始揭示在发育和细菌感染的背景下20E免疫调节的潜在机制。最后，我对20E免疫调节的未来研究方向提出了建议，这将促进我们对交互内分泌网络如何协调动物对环境微生物的生理反应的了解。
Endocrine signaling networks control diverse biological processes and life history traits across metazoans. In both invertebrate and vertebrate taxa, steroid hormones regulate immune system function in response to intrinsic and environmental stimuli, such as microbial infection. The mechanisms of this endocrine-immune regulation are complex and constitute an ongoing research endeavor facilitated by genetically tractable animal models. The 20-hydroxyecdysone (20E) is the major steroid hormone in arthropods, primarily studied for its essential role in mediating developmental transitions and metamorphosis; 20E also modulates innate immunity in a variety of insect taxa. This review provides an overview of our current understanding of 20E-mediated innate immune responses. The prevalence of correlations between 20E-driven developmental transitions and innate immune activation are summarized across a range of holometabolous insects. Subsequent discussion focuses on studies conducted using the extensive genetic resources available in Drosophila that have begun to reveal the mechanisms underlying 20E regulation of immunity in the contexts of both development and bacterial infection. Lastly, I propose directions for future research into 20E regulation of immunity that will advance our knowledge of how interactive endocrine networks coordinate animals’ physiological responses to environmental microbes.
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