Regulating metabolism to shape immune function: Lessons from Drosophila.
Regulating metabolism to shape immune function: Lessons from Drosophila.
复制标题
DOI：
10.1016/j.semcdb.2022.04.002
复制
发表时间：
2023-03-30
影响因子：
7.3
通讯作者：
Bland, Michelle L.
中科院分区：
文献类型：
--
作者：
Bland, Michelle L.
病原微生物感染是宿主通过激活先天免疫反应来管理的严重威胁。在黑腹果蝇中，Toll和Imd信号通路被病原体相关的分子模式激活，从而启动细胞和体液免疫过程，从而中和和杀死入侵者。Toll和Imd信号通路在控制宿主营养代谢的脂肪体和肠道等器官中起作用，Toll和Imd信号的感染或遗传激活也会引起宿主脂质、碳水化合物和蛋白质代谢的广泛变化。免疫信号的代谢调节可以赋予对感染的抵抗力或耐受性，但它也可以导致病理和对感染的易感性。本综述描述了这些免疫代谢表型，以及在感染期间介导生存的内分泌信号和基因调控的变化。该领域未来的工作预计将确定改变免疫代谢表型的关键变量，如性别、膳食营养素、生命阶段和病原体特征，更重要的是，揭示免疫系统调节代谢的机制。
Infection with pathogenic microbes is a severe threat that hosts manage by activating the innate immune response. In Drosophila melanogaster, the Toll and Imd signaling pathways are activated by pathogen-associated molecular patterns to initiate cellular and humoral immune processes that neutralize and kill invaders. The Toll and Imd signaling pathways operate in organs such as fat body and gut that control host nutrient metabolism, and infections or genetic activation of Toll and Imd signaling also induce wide-ranging changes in host lipid, carbohydrate and protein metabolism. Metabolic regulation by immune signaling can confer resistance to or tolerance of infection, but it can also lead to pathology and susceptibility to infection. These immunometabolic phenotypes are described in this review, as are changes in endocrine signaling and gene regulation that mediate survival during infection. Future work in the field is anticipated to determine key variables such as sex, dietary nutrients, life stage, and pathogen characteristics that modify immunometabolic phenotypes and, importantly, to uncover the mechanisms used by the immune system to regulate metabolism.
登录
查看更多内容
苍蝇如何以及为什么会关闭其免疫系统？
影响因子：
9.8
作者：
Schneider, David S.
通讯作者：
Schneider, David S.
影响因子：
9.8
作者：
Bajgar A;Kucerova K;Jonatova L;Tomcala A;Schneedorferova I;Okrouhlik J;Dolezal T
通讯作者：
Dolezal T
影响因子：
4.5
作者：
Bai H;Kang P;Hernandez AM;Tatar M
通讯作者：
Tatar M
影响因子：
13.6
作者：
Chatterjee N;Perrimon N
通讯作者：
Perrimon N
影响因子：
11.8
作者：
Boutros, M;Agaisse, H;Perrimon, N
通讯作者：
Perrimon, N