A novel device for studying weight supported, quadrupedal overground locomotion in spinal cord injured rats.
A novel device for studying weight supported, quadrupedal overground locomotion in spinal cord injured rats.
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DOI：
10.1016/j.jneumeth.2015.03.015
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发表时间：
2015-05-15
影响因子：
3
通讯作者：
de Leon, Ray D.
中科院分区：
文献类型：
--
作者：
Hamlin, Marvin;Traughber, Terence, Jr.;Reinkensmeyer, David J.;de Leon, Ray D.
提供重量支撑有助于脊髓损伤动物的运动。为了控制重量支撑，机器人系统已被开发用于跑步机行走，最近又被开发用于地面行走。我们开发了一种新颖的设备，即体重支撑的动态啮齿动物训练器（即 BART）。它有一个小型气缸，可以沿着老鼠上方的线性轨道移动。当向圆筒供应空气时，老鼠在地上行走时被举起。我们在遭受中度脊髓挫伤的大鼠和正常大鼠中测试了 BART 装置。未使用 BART 设备进行运动训练。所有的老鼠都学会了在 BART 装置中行走。在挫伤的大鼠中，与正常大鼠相比，后肢发生明显更大的爪子拖拽和背侧迈步。提供重量支撑可显着提高臀部位置并显着减少运动缺陷。后肢迈步与前肢迈步紧密结合，但仅当挫伤的大鼠在没有重量支撑的情况下迈步时。挫伤大鼠接受完整脊髓横断后三周，后肢行走次数显着减少。相对于啮齿动物机器人系统，BART 设备是用于研究地面运动的更简单的系统。 BART 设备缺乏复杂的控制和传感能力，但其组装相对容易且便宜。这些发现表明，BART 设备是评估四足地面运动的有用工具，四足动物的地上运动是一种比跑步机运动更自然的运动形式。
Providing weight support facilitates locomotion in spinal cord injured animals. To control weight support, robotic systems have been developed for treadmill stepping and more recently for overground walking. We developed a novel device, the body weight supported ambulatory rodent trainer (i.e. BART). It has a small pneumatic cylinder that moves along a linear track above the rat. When air is supplied to the cylinder, the rats are lifted as they perform overground walking. We tested the BART device in rats that received a moderate spinal cord contusion injury and in normal rats. Locomotor training with the BART device was not performed. All of the rats learned to walk in the BART device. In the contused rats, significantly greater paw dragging and dorsal stepping occurred in the hindlimbs compared to normal. Providing weight support significantly raised hip position and significantly reduced locomotor deficits. Hindlimb stepping was tightly coupled to forelimb stepping but only when the contused rats stepped without weight support. Three weeks after the contused rats received a complete spinal cord transection, significantly fewer hindlimb steps were performed. Relative to rodent robotic systems, the BART device is a simpler system for studying overground locomotion. The BART device lacks sophisticated control and sensing capability, but it can be assembled relatively easily and cheaply. These findings suggest that the BART device is a useful tool for assessing quadrupedal, overground locomotion which is a more natural form of locomotion relative to treadmill locomotion.
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影响因子：
4.2
作者：
de Leon, Ray D.;Acosta, Cynthia N.
通讯作者：
Acosta, Cynthia N.
影响因子：
5.3
作者：
Kuerzi, J.;Brown, E. H.;Magnuson, D. S. K.
通讯作者：
Magnuson, D. S. K.
影响因子：
56.9
作者：
van den Brand, Rubia;Heutschi, Janine;Courtine, Gregoire
通讯作者：
Courtine, Gregoire
影响因子：
82.9
作者：
Dominici, Nadia;Keller, Urs;Courtine, Gregoire
通讯作者：
Courtine, Gregoire
影响因子：
14.5
作者：
Shah, Prithvi K.;Garcia-Alias, Guillermo;Edgerton, V. Reggie
通讯作者：
Edgerton, V. Reggie