Effects of Dietary Protein Source and Quantity on Bone Morphology and Body Composition Following a High-Protein Weight-Loss Diet in a Rat Model for Postmenopausal Obesity.
Effects of Dietary Protein Source and Quantity on Bone Morphology and Body Composition Following a High-Protein Weight-Loss Diet in a Rat Model for Postmenopausal Obesity.
复制标题
DOI：
10.3390/nu14112262
复制
发表时间：
2022-05-28
期刊：
影响因子：
5.9
通讯作者：
Main, Russell P.
中科院分区：
文献类型：
--
作者：
Wright, Christian S.;Hill, Erica R.;Reyes Fernandez, Perla C.;Thompson, William R.;Gallant, Maxime A.;Campbell, Wayne W.;Main, Russell P.
高蛋白(占总能量的30%，HP)-能量限制(HP-ER)饮食是改善身体成分和代谢健康的有效手段。然而，体重减轻(WL)与骨质丢失有关，HP-ER饮食对骨骼的影响是混合的，也是有争议的。最近的证据表明，相互矛盾的结果可能源于年龄、荷尔蒙状况和饮食蛋白质消费的主要来源的差异。因此，本研究研究了四种不同蛋白质来源(牛肉、牛奶、大豆、酪蛋白)和蛋白质含量(正常蛋白质，NP为15%，高蛋白质为35%)的12周能量限制(ER)饮食对32周龄肥胖去卵巢雌性大鼠骨和身体成分结果的影响。总体而言，雌激素受体降低了体重、骨量(aBMD、ABMC)、骨微结构和身体成分参数。与HP牛肉和HP大豆日粮相比，NP日粮的WL更大，肌肉面积只随着NP日粮的减少而减少。与HP大豆饮食相比，HP牛肉饮食加剧了WL诱导的骨丢失(增加了骨小梁分离率和皮质内骨形成率，降低了骨保持率和骨小梁密度，增加了棒状骨小梁)。HP-牛奶饮食不会增加WL诱导的骨丢失。结果表明，在绝经后肥胖模型中，可能需要特定的蛋白质来源建议来减轻HP-ER饮食后骨骼质量的不利变化。
Higher protein (>30% of total energy, HP)-energy restriction (HP-ER) diets are an effective means to improve body composition and metabolic health. However, weight loss (WL) is associated with bone loss, and the impact of HP-ER diets on bone is mixed and controversial. Recent evidence suggests conflicting outcomes may stem from differences in age, hormonal status, and the predominant source of dietary protein consumed. Therefore, this study investigated the effect of four 12-week energy restriction (ER) diets varying in predominate protein source (beef, milk, soy, casein) and protein quantity (normal protein, NP 15% vs. high, 35%) on bone and body composition outcomes in 32-week-old obese, ovariectomized female rats. Overall, ER decreased body weight, bone quantity (aBMD, aBMC), bone microarchitecture, and body composition parameters. WL was greater with the NP vs. HP-beef and HP-soy diets, and muscle area decreased only with the NP diet. The HP-beef diet exacerbated WL-induced bone loss (increased trabecular separation and endocortical bone formation rates, lower bone retention and trabecular BMC, and more rod-like trabeculae) compared to the HP-soy diet. The HP-milk diet did not augment WL-induced bone loss. Results suggest that specific protein source recommendations may be needed to attenuate the adverse alterations in bone quality following an HP-ER diet in a model of postmenopausal obesity.
登录
查看更多内容
影响因子：
120.7
作者：
Flegal, Katherine M.;Carroll, Margaret D.;Curtin, Lester R.
通讯作者：
Curtin, Lester R.
影响因子：
2.8
作者：
Chen H;Zhou X;Fujita H;Onozuka M;Kubo KY
通讯作者：
Kubo KY
影响因子：
6.2
作者：
Fenton, Tanis R.;Lyon, Andrew W.;Hanley, David A.
通讯作者：
Hanley, David A.
DOI：
10.1016/j.jand.2012.11.002
发表时间：
2013-03-01
影响因子：
4.8
作者：
Bihuniak, Jessica D.;Simpson, Christine A.;Insogna, Karl L.
通讯作者：
Insogna, Karl L.
影响因子：
7.1
作者：
Heaney, Robert P.;Layman, Donald K.
通讯作者：
Layman, Donald K.