Age-related changes in trabecular and cortical bone microstructure.
Age-related changes in trabecular and cortical bone microstructure.
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DOI：
10.1155/2013/213234
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发表时间：
2013
影响因子：
2.8
通讯作者：
Kubo KY
中科院分区：
文献类型：
--
作者：
Chen H;Zhou X;Fujita H;Onozuka M;Kubo KY
全世界的老年人口大幅增加。衰老是一个复杂的过程，衰老的影响是无数的和阴险的，导致包括骨骼在内的各种器官的逐步退化。在老年人群中，与骨丢失相关的骨质疏松症增加了骨折和发病率的风险。骨质疏松症是与衰老相关的最常见疾病之一，年龄是骨质疏松性骨折的独立危险因素。随着计算机断层扫描（CT）、micro-CT和高分辨率外周定量CT（HR-pQCT）等非侵入性成像技术的发展，骨结构成像提供了有关骨微观结构年龄相关变化和骨强度估计的重要信息。在过去的二十年里，使用成像技术对人体标本的研究表明，与年轻人相比，老年人的骨强度下降。本文主要基于HR-pQCT和micro-CT，讨论了最近研究的骨小梁和皮质骨微结构的年龄相关变化。我们特别关注椎骨、股骨颈和桡骨远端的三维显微结构，这些都是常见的骨质疏松性骨折部位。
The elderly population has substantially increased worldwide. Aging is a complex process, and the effects of aging are myriad and insidious, leading to progressive deterioration of various organs, including the skeleton. Age-related bone loss and resultant osteoporosis in the elderly population increase the risk for fractures and morbidity. Osteoporosis is one of the most common conditions associated with aging, and age is an independent risk factor for osteoporotic fractures. With the development of noninvasive imaging techniques such as computed tomography (CT), micro-CT, and high resolution peripheral quantitative CT (HR-pQCT), imaging of the bone architecture provides important information about age-related changes in bone microstructure and estimates of bone strength. In the past two decades, studies of human specimens using imaging techniques have revealed decreased bone strength in older adults compared with younger adults. The present paper addresses recently studied age-related changes in trabecular and cortical bone microstructure based primarily on HR-pQCT and micro-CT. We specifically focus on the three-dimensional microstructure of the vertebrae, femoral neck, and distal radius, which are common osteoporotic fracture sites.
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影响因子：
4.1
作者：
Ding, M;Hvid, I
通讯作者：
Hvid, I
影响因子：
4.5
作者：
HARRIGAN, TP;MANN, RW
通讯作者：
MANN, RW
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Chen, H.;Shoumura, S.;Bunai, Y.
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Bunai, Y.
影响因子：
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作者：
Eckstein, F;Fischbeck, M;Lochmüller, EM
通讯作者：
Lochmüller, EM
影响因子：
4
作者：
Chen, H.;Zhou, X.;Bunai, Y.
通讯作者：
Bunai, Y.