Dietary regulation in health and disease.
Dietary regulation in health and disease.
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DOI：
10.1038/s41392-022-01104-w
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发表时间：
2022-07-23
影响因子：
39.3
通讯作者：
Wang, Ping
中科院分区：
文献类型：
--
作者：
Wu, Qi;Gao, Zhi-Jie;Yu, Xin;Wang, Ping
营养素被认为影响所有的生理病理过程。最近的分子医学和临床试验证据表明，充足的营养治疗是延长酵母、果蝇、啮齿动物、灵长类和人类等各种物种的健康寿命和延缓衰老的金标准。它的出现是为了开发精确营养疗法，以减缓与年龄相关的生物过程，并治疗各种疾病。然而，营养优势在个体之间以及器官和组织之间往往是多样化的，这给这一领域带来了挑战。在这篇综述中，我们总结了不同形式的饮食干预，广泛用于改善健康寿命和疾病治疗，在临床前或临床。我们讨论了营养调节机制，包括代谢调节、营养代谢途径、表观遗传机制和生物钟。相比之下，我们描述了饮食反应效应，饮食干预通过这些效应影响内分泌、免疫、微生物和神经状态，这些状态负责改善人类健康和预防多种疾病。此外，我们还阐述了不同的饮食模式，包括不同的禁食、卡路里限制饮食、生酮饮食、高纤维饮食、植物性饮食、蛋白质限制饮食或特定减少氨基酸或微量元素的饮食，这些饮食可能影响健康和疾病状态。总之，我们强调深刻的营养治疗，并强调探索的机制和关键因素之间的串扰，以开发个性化的治疗方法和预测因素。
Nutriments have been deemed to impact all physiopathologic processes. Recent evidences in molecular medicine and clinical trials have demonstrated that adequate nutrition treatments are the golden criterion for extending healthspan and delaying ageing in various species such as yeast, drosophila, rodent, primate and human. It emerges to develop the precision-nutrition therapeutics to slow age-related biological processes and treat diverse diseases. However, the nutritive advantages frequently diversify among individuals as well as organs and tissues, which brings challenges in this field. In this review, we summarize the different forms of dietary interventions extensively prescribed for healthspan improvement and disease treatment in pre-clinical or clinical. We discuss the nutrient-mediated mechanisms including metabolic regulators, nutritive metabolism pathways, epigenetic mechanisms and circadian clocks. Comparably, we describe diet-responsive effectors by which dietary interventions influence the endocrinic, immunological, microbial and neural states responsible for improving health and preventing multiple diseases in humans. Furthermore, we expatiate diverse patterns of dietotheroapies, including different fasting, calorie-restricted diet, ketogenic diet, high-fibre diet, plants-based diet, protein restriction diet or diet with specific reduction in amino acids or microelements, potentially affecting the health and morbid states. Altogether, we emphasize the profound nutritional therapy, and highlight the crosstalk among explored mechanisms and critical factors to develop individualized therapeutic approaches and predictors.
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影响因子：
5
作者：
Alessandro, Rubini;Gerardo, Bosco;Antonio, Paoli
通讯作者：
Antonio, Paoli
影响因子：
4.2
作者：
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通讯作者：
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DOI：
10.1126/science.aaw9872
发表时间：
2020-04-03
期刊：
Science (New York, N.Y.)
影响因子：
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作者：
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通讯作者：
Olive KP
DOI：
10.1016/j.bbalip.2015.01.013
发表时间：
2015-05-01
影响因子：
4.8
作者：
Baumeier, Christian;Kaiser, Daniel;Schuermann, Annette
通讯作者：
Schuermann, Annette
影响因子：
29
作者：
Brandhorst S;Choi IY;Wei M;Cheng CW;Sedrakyan S;Navarrete G;Dubeau L;Yap LP;Park R;Vinciguerra M;Di Biase S;Mirzaei H;Mirisola MG;Childress P;Ji L;Groshen S;Penna F;Odetti P;Perin L;Conti PS;Ikeno Y;Kennedy BK;Cohen P;Morgan TE;Dorff TB;Longo VD
通讯作者：
Longo VD