Effects of aging and calorie restriction on white matter in rhesus macaques.
Effects of aging and calorie restriction on white matter in rhesus macaques.
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DOI：
10.1016/j.neurobiolaging.2010.04.008
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发表时间：
2011-12
影响因子：
4.2
通讯作者：
Johnson SC
中科院分区：
文献类型：
--
作者：
Bendlin BB;Canu E;Willette A;Kastman EK;McLaren DG;Kosmatka KJ;Xu G;Field AS;Colman RJ;Coe CL;Weindruch RH;Alexander AL;Johnson SC
热量限制饮食（CR）的恒河猴发展较少的年龄相关疾病，几乎没有糖尿病的迹象，防止肌肉减少症，并可能活得更长。CR的有益效果可能包括减少与年龄相关的炎症和氧化损伤。少突胶质细胞对炎症和氧化应激特别敏感，因此，我们假设CR对脑白色物质具有有益作用，并将减弱该组织中与年龄相关的衰退。CR猴和对照组进行扩散张量成像（DTI）。在上级纵束、额枕束、外囊和脑干中观察到DTI指数的CR的有益效果。在几个区域观察到衰老效应，尽管CR似乎减弱了上级纵束、额叶白色物质、外囊、右侧海马旁白色物质和枕背束的年龄相关改变。然而，结果是区域特异性的，并且还表明CR并不是对所有白色物质都有益。对这一独特的老年灵长类动物死亡率队列的进一步评估将揭示成年发病、中度CR饮食对延缓脑老化的最终益处。
Rhesus macaques on a calorie restricted diet (CR) develop less age-related disease, have virtually no indication of diabetes, are protected against sarcopenia, and potentially live longer. Beneficial effects of CR likely include reductions in age-related inflammation and oxidative damage. Oligodendrocytes are particularly susceptible to inflammation and oxidative stress, therefore, we hypothesized that CR would have a beneficial effect on brain white matter and would attenuate age-related decline in this tissue. CR monkeys and controls underwent diffusion tensor imaging (DTI). A beneficial effect of CR indexed by DTI was observed in superior longitudinal fasciculus, fronto-occipital fasciculus, external capsule, and brainstem. Aging effects were observed in several regions, although CR appeared to attenuate age-related alterations in superior longitudinal fasciculus, frontal white matter, external capsule, right parahippocampal white matter and dorsal occipital bundle. The results, however, were regionally specific and also suggested that CR is not salutary across all white matter. Further evaluation of this unique cohort of elderly primates to mortality will shed light on the ultimate benefits of an adult-onset, moderate CR diet for deferring brain aging.
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DOI：
10.1126/science.1173635
发表时间：
2009-07-10
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Colman RJ;Anderson RM;Johnson SC;Kastman EK;Kosmatka KJ;Beasley TM;Allison DB;Cruzen C;Simmons HA;Kemnitz JW;Weindruch R
通讯作者：
Weindruch R
影响因子：
5.8
作者：
Haltia, Lauri T.;Viljanen, Antti;Kaasinen, Valtteri
通讯作者：
Kaasinen, Valtteri
DOI：
10.1016/j.jmr.2011.09.022
发表时间：
1996-06-01
期刊：
JOURNAL OF MAGNETIC RESONANCE SERIES B
影响因子：
--
作者：
Basser, PJ;Pierpaoli, C
通讯作者：
Pierpaoli, C
影响因子：
6.7
作者：
Jung, K. J.;Lee, E. K.;Chung, H. Y.
通讯作者：
Chung, H. Y.
影响因子：
19.7
作者：
Courchesne, E;Chisum, HJ;Press, GA
通讯作者：
Press, GA