Anti‐promoting Effect of Nordihydroguaiaretic Acid on N‐Butyl‐N‐(4‐hydroxybutyl)nitrosamine and Sodium Saccharin‐induced Rat Urinary Bladder Carcinogenesis
Anti‐promoting Effect of Nordihydroguaiaretic Acid on N‐Butyl‐N‐(4‐hydroxybutyl)nitrosamine and Sodium Saccharin‐induced Rat Urinary Bladder Carcinogenesis
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去甲二氢愈创木酸对N-丁基-N-(4-羟丁基)亚硝胺和糖精钠诱导的大鼠膀胱癌的抗促进作用
DOI：
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发表时间：
1992
期刊：
影响因子：
--
通讯作者：
O. Yoshida
中科院分区：
文献类型：
--
作者：
A. Yu;T. Hashimura;Y. Nishio;H. Kanamaru;S. Fukuzawa;O. Yoshida
研究了口服去甲二氢愈创木酸（NDGA）（一种抗氧化剂和花生四烯酸代谢抑制剂）对大鼠膀胱癌发生的影响。六周龄雄性 Fischer 344 大鼠饮用含有 0.05% N-丁基-N-(4-羟丁基)亚硝胺的水 4 周。在这 4 周之后，大鼠接受含有 5% 糖精钠 (SS) 并添加或不添加 0.1% NDGA 补充剂的饮食，持续 36 周。 SS加NDGA治疗组中乳头状或结节性(PN)增生和乳头状瘤的发生率显着低于单独SS治疗组。用SS加NDGA治疗的大鼠中每10cm基底膜的PN增生灶的数量也低于单独用SS治疗的组。这些结果表明NDGA对大鼠膀胱癌的发生具有抗肿瘤促进作用。
The effects of oral administration of nordihydroguaiaretic acid (NDGA), an antioxidant and inhibitor of arachidonic acid metabolism, on rat bladder carcinogenesis were examined. Six‐week‐old male Fischer 344 rats were given drinking watar containing 0.05% N‐butyl‐N‐(4‐hydroxybutyl)nitrosamine for 4 weeks. Following this 4‐week period, diet containing 5% sodium saccharin (SS) with or without 0.1% NDGA supplement was given to the rats for 36 weeks. The incidences of papillary or nodular (PN) hyperplasia and of papilloma in the group treated with SS plus NDGA were significantly lower than those in the group treated with SS alone. The number of PN hyperplasic foci per 10 cm of basement membrane in rats treated with SS plus NDGA was also lower than that in the group treated with SS alone. These results suggest that NDGA has an anti‐tumor‐promoting effect on rat bladder carcinogenesis.
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阿司匹林抑制 N-[4-(5-硝基-2-呋喃基)-2-噻唑基]甲酰胺起始和糖精钠促进雄性 F344 大鼠膀胱癌的发生。
影响因子：
11.2
作者：
Sakata,T;Hasegawa,R;Johansson,SL;Zenser,TV;Cohen,SM
通讯作者：
Cohen,SM
影响因子：
56.9
作者：
AMES, BN
通讯作者：
AMES, BN
影响因子：
9.7
作者：
D. Mccormick;A. M. Spicer
通讯作者：
D. Mccormick;A. M. Spicer
浅表和局部晚期人类膀胱癌的分子遗传改变。
影响因子：
11.2
作者：
PrestiJr,JC;Reuter,VE;Galan,T;Fair,WR;Cordon-Cardo,C
通讯作者：
Cordon-Cardo,C