Lifetime cancer prevalence and life history traits in mammals.
Lifetime cancer prevalence and life history traits in mammals.
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DOI：
10.1093/emph/eoaa015
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发表时间：
2020
期刊：
影响因子：
--
通讯作者：
Witte C
中科院分区：
文献类型：
--
作者：
Boddy AM;Abegglen LM;Pessier AP;Aktipis A;Schiffman JD;Maley CC;Witte C
癌症是许多哺乳动物的常见诊断，但它们对癌症的易感性各不相同。驱动这种变异的因素尚不清楚，但生活史理论为为什么癌症防御机制在不同物种之间不同提供了潜在的解释。在这里，我们使用圣地亚哥动物园和圣地亚哥动物园野生动物园42年来精心整理的尸检数据，报告了代表11个哺乳动物目的37个哺乳动物物种的肿瘤和恶性肿瘤的流行情况。我们收集了这些物种的生活史成分的数据，并测试了生活史特征与肿瘤和恶性肿瘤之间的关联，同时控制了系统发育史。这些结果支持皮托悖论，因为我们没有发现寿命和/或体重与肿瘤或恶性肿瘤的流行之间的联系。然而，产仔数与恶性肿瘤患病率之间存在正相关关系(P = 0.005，Adj.R2=0.212)，这表明一个物种的生活史策略可能会影响癌症的易感性。最后，我们测试了胎盘侵袭性和恶性之间的关系。我们没有发现胎盘深度和恶性肿瘤患病率之间存在关联的证据(P = 0.618，调整R2=0.068)。生活史理论为理解生命之树上癌症防御的差异提供了一个强大的框架。这些发现提供了对生活史特征和癌症易感性之间的关系的洞察，这表明生殖和癌症防御之间存在权衡。为什么有些哺乳动物比其他哺乳动物更容易患癌症？我们测试生命史权衡是否可以解释癌症风险的这种变化。与体型较小、寿命较短的动物相比，体型较大、寿命较长的动物不会患上更多癌症。然而，我们发现哺乳动物的产仔数和癌症患病率之间存在正相关。
Cancer is a common diagnosis in many mammalian species, yet they vary in their vulnerability to cancer. The factors driving this variation are unknown, but life history theory offers potential explanations to why cancer defense mechanisms are not equal across species. Here we report the prevalence of neoplasia and malignancy in 37 mammalian species, representing 11 mammalian orders, using 42 years of well curated necropsy data from the San Diego Zoo and San Diego Zoo Safari Park. We collected data on life history components of these species and tested for associations between life history traits and both neoplasia and malignancy, while controlling for phylogenetic history. These results support Peto’s paradox, in that we find no association between lifespan and/or body mass and the prevalence of neoplasia or malignancy. However, a positive relationship exists between litter size and prevalence of malignancy (P = 0.005, Adj. R2 = 0.212), suggesting that a species’ life history strategy may influence cancer vulnerabilities. Lastly, we tested for the relationship between placental invasiveness and malignancy. We find no evidence for an association between placental depth and malignancy prevalence (P = 0.618, Adj. R2 = 0.068). Life history theory offers a powerful framework to understand variation in cancer defenses across the tree of life. These findings provide insight into the relationship between life history traits and cancer vulnerabilities, which suggest a trade-off between reproduction and cancer defenses. Why are some mammals more vulnerable to cancer than others? We test whether life history trade-offs may explain this variation in cancer risk. Bigger, longer-lived animals do not develop more cancer compared to smaller, shorter-lived animals. However, we find a positive association between litter size and cancer prevalence in mammals.
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影响因子：
3.8
作者：
Capellini, I.
通讯作者：
Capellini, I.
DOI：
10.1001/jama.2015.13134
发表时间：
2015-11-03
期刊：
JAMA
影响因子：
--
作者：
Abegglen LM;Caulin AF;Chan A;Lee K;Robinson R;Campbell MS;Kiso WK;Schmitt DL;Waddell PJ;Bhaskara S;Jensen ST;Maley CC;Schiffman JD
通讯作者：
Schiffman JD
影响因子：
--
作者：
Albuquerque TAF;Drummond do Val L;Doherty A;de Magalhães JP
通讯作者：
de Magalhães JP
影响因子：
5.2
作者：
Gründker C;Emons G
通讯作者：
Emons G
影响因子：
10.3
作者：
EFFRON, M;GRINER, L;BENIRSCHKE, K
通讯作者：
BENIRSCHKE, K