Expression of TWIST, an inducer of epithelial-mesenchymal transition, in nasopharyngeal carcinoma and its clinical significance.
Expression of TWIST, an inducer of epithelial-mesenchymal transition, in nasopharyngeal carcinoma and its clinical significance.
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上皮间质转化诱导剂TWIST在鼻咽癌中的表达及其临床意义
DOI：
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发表时间：
2014-12
期刊：
影响因子：
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通讯作者：
Zhou, Yan
中科院分区：
文献类型：
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作者：
Zhuo, Xianlu;Chang, Aoshuang;Huang, Chuang;Yang, Li;Xiang, Zhaolan;Zhou, Yan
上皮间质转化（EMT）与许多癌症的发生有关。一种重要的 EMT 诱导剂 TWIST 已被发现在多种肿瘤中过度表达，但在鼻咽癌 (NPC) 中的研究很少。本研究旨在探讨鼻咽癌中TWIST的表达及其与临床病理因素和预后的关系。本研究共涉及 65 例鼻咽癌样本和 20 例正常样本。采用RT-PCR和免疫组化方法检测鼻咽癌和正常组织中TWIST mRNA和蛋白的表达。分析TWIST表达水平与鼻咽癌患者临床特征及预后的关系。鼻咽癌组织中TWIST表达阳性率明显高于正常组织。 TWIST 的过度表达与 N 分期和远处转移的存在相关。相对于TWIST表达阴性的患者，TWIST表达阳性的患者的总生存时间显着缩短。数据表明，TWIST 过表达与鼻咽癌的淋巴和远处转移相关。此外，它可能是预测晚期肿瘤进展的新型生物标志物和潜在的不利预后因素以及鼻咽癌的潜在治疗靶点。
Epithelial-mesenchymal transition (EMT) has been implicated in the development of a number of cancers. An important EMT inducer, TWIST, has been detected to be over-expressed in a variety of tumors, but rarely been studied in nasopharyngeal carcinoma (NPC). This study aimed to examine TWIST expression and its association with clinicopathological factors and prognosis in NPC. A total of 65 NPC and 20 normal samples were involved in the present study. RT-PCR and immunohistochemistry were used to examine the mRNA and protein expressions of TWIST in NPC and normal tissues. The relationship of TWIST expression levels with clinical features and prognosis of NPC patients were analyzed. The positive rate of TWIST expression was markedly higher in NPC tissues than that in normal tissues. Over-expression of TWIST was correlated with N stage and the presence of distant metastasis. Patients with positive TWIST expression had a significantly shorter overall survival time relative to patients with negative TWIST expression. The data suggest that TWIST over-expression has a correlation with lymphatic and distant metastasis in NPC. Moreover, it might be a novel biomarker for prediction of advanced tumor progression and a potential unfavorable prognostic factor as well as a potential treatment target for NPC.
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