Hedysari extract improves regeneration after peripheral nerve injury by enhancing the amplification effect.
Hedysari extract improves regeneration after peripheral nerve injury by enhancing the amplification effect.
复制标题
红芪提取物通过增强放大效应改善周围神经损伤后的再生
DOI：
10.1371/journal.pone.0067921
复制
发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Jiang B
中科院分区：
文献类型：
--
作者：
Wang Z;Zhang P;Kou Y;Yin X;Han N;Jiang B
红芪是一种在传统中医药中经常使用的草药制剂。它能够促进周围神经损伤后的再生，但是其对周围神经再生过程中放大比率（远端纤维与近端纤维的比率）的影响尚未得到研究。在本研究中，我们探究了红芪提取物对周围神经放大比率的影响。将雄性Sprague - Dawley大鼠随机分为三组：正常组（不进行手术）、模型组（给予套管神经桥接手术，但不进行辅助治疗）和治疗组（给予套管神经桥接手术，然后给予红芪提取物作为辅助治疗）。手术后12周，进行一般观察、电生理检查、组织学分析、形态测量以及放大比率计算。结果显示，治疗组的神经传导速度、纤维和轴突直径、g比率、再生神经纤维数量以及放大比率均优于模型组，这表明红芪提取物能够有效促进近端神经残端侧芽的生长，并显著改善周围神经再生过程中的放大效应。
Radix Hedysari is an herbal preparation frequently used in traditional Chinese medicine. It can promote regeneration after peripheral nerve injury, but its effect on the amplification ratio (the ratio of distal to proximal fibers) during peripheral nerve regeneration has not yet been examined. In this study, we explored the effect of Hedysari extract on the amplification ratio in the peripheral nerve. Male Sprague-Dawley rats were separated into three groups at random: normal group (without surgery), model group (given sleeve nerve bridging surgery, but without adjuvant treatment) and treatment group (given sleeve nerve bridging surgery and then given Hedysari extract as adjuvant treatment). Twelve weeks after surgery, general observations, electrophysiological examination, histological analysis, morphometric measurements, and amplification ratio calculations were made. The results showed that nerve conduction velocity, the fiber and axon diameter, the g-ratio, the number of regenerating nerve fibers and the amplification ratio were better in the treatment group than in the model group, suggesting that Hedysari extract can effectively promote the growth of lateral buds in the proximal nerve stump and substantially improve the amplification effect during peripheral nerve regeneration.
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