Tunnelling readout of hydrogen-bonding-based recognition.
Tunnelling readout of hydrogen-bonding-based recognition.
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DOI：
10.1038/nnano.2009.48
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发表时间：
2009-05
影响因子：
38.3
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中科院分区：
文献类型：
--
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氢键在电子传递和分子识别中起着无处不在的作用，DNA碱基配对就是最著名的例子。扫描隧道显微镜(STM)的图像和测量结果表明，当分子结被STM尖端拉开时，隧道电流的衰减对氢键相互作用很敏感。在这里，我们展示了这些隧道衰变信号可以用来测量DNA碱基中氢键的强度。每个碱基上由三个氢键结合在一起的连接(例如，鸟嘌呤-胞嘧啶相互作用)比每个碱基上两个氢键结合的连接(例如，腺嘌呤-胸腺嘧啶相互作用)更坚硬。在隧道探头的接近上也观察到了类似但不那么明显的影响，这意味着依赖于氢键的吸引力也在决定电流的上升中发挥作用。这些效应为制造将分子识别事件转化为电子信号的传感器提供了新的机制。
Hydrogen bonding has a ubiquitous role in electron transport and in molecular recognition, with DNA base-pairing being the best known example. Scanning tunneling microscope (STM) images and measurements of the decay of tunnel-current as a molecular junction is pulled apart by the STM tip, are sensitive to hydrogen-bonded interactions. Here we show that these tunnel-decay signals can be used to measure the strength of hydrogen bonding in DNA basepairs. Junctions that are held together by three hydrogen bonds per basepair (e.g., guanine-cytosine interactions) are stiffer than junctions held together by two hydrogen bonds per basepair (e.g., adenine-thymine interactions). Similar, but less-pronounced, effects are observed on the approach of the tunneling probe, implying that hydrogen-bond dependent attractive forces also have a role in determining the rise of current. These effects provide new mechanisms for making sensors that transduce a molecular recognition event into an electronic signal.
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影响因子：
1.6
作者：
HUTTER, JL;BECHHOEFER, J
通讯作者：
BECHHOEFER, J
影响因子：
4
作者：
He, Jin;Chen, Fan;Nuckolls, Colin
通讯作者：
Nuckolls, Colin
影响因子：
10.8
作者：
He, Jin;Lin, Lisha;Lindsay, Stuart
通讯作者：
Lindsay, Stuart
影响因子：
8.6
作者：
Tao, NJ
通讯作者：
Tao, NJ
影响因子：
3.7
作者：
Troisi, A;Ratner, MA
通讯作者：
Ratner, MA