Low and high responders to pharmacological doses of beta-carotene: proportion in the population, mechanisms involved and consequences on beta-carotene metabolism.
Low and high responders to pharmacological doses of beta-carotene: proportion in the population, mechanisms involved and consequences on beta-carotene metabolism.
复制标题
对药理剂量 β-胡萝卜素的低反应和高反应者：人群中的比例、涉及的机制以及对 β-胡萝卜素代谢的影响。
作者：
P. Borel;P. Grolier;N. Mekki;Y. Boirie;Y. Rochette;B. L. Roy;M. Alexandre;D. Lairon;V. Azaı̈s
本研究的目的是评估乳糜微粒β-胡萝卜素对人群中β-胡萝卜素药理负荷反应的个体间变异性，以确定导致这种变异性的机制，并评估其对β-胡萝卜素状态和代谢的影响。在79名健康男性志愿者中，通过3小时乳糜微粒β-胡萝卜素对120 mg β-胡萝卜素的反应估计的变异性很高（CV = 61%），但它是单峰的，所有受试者都有可检测到的乳糜微粒β-胡萝卜素。在79名受试者中随机选择的16名受试者中，依地平调整的乳糜微粒（β-胡萝卜素+棕榈酸视黄酯）反应（0-12.5 h曲线下面积）的个体间变异性较高（CV = 54%），表明β-胡萝卜素的肠道吸收效率存在较高的个体间变异性。乳糜微粒β-胡萝卜素反应与乳糜微粒甘油三酯反应相关（r = 0.50，P < 0.05）。通过颊粘膜细胞中β-胡萝卜素浓度评估的β-胡萝卜素状态与依那普利调节的乳糜微粒β-胡萝卜素反应相关（r = 0.73，P < 0.05），即，对β-胡萝卜素有反应的能力。维生素A调节的乳糜微粒视黄酸棕榈酸酯反应与维生素A调节的乳糜微粒β-胡萝卜素反应相关（r = 0.55，P < 0.05）。β-胡萝卜素负荷后3小时，血浆全反式维甲酸轻微但显著增加（+40%），但这种增加与β-胡萝卜素调节的反应无关。总之，对β-胡萝卜素的反应能力是高度可变的，但在健康人群中，对药理剂量的β-胡萝卜素真正无反应者的比例可能很小。这种变异性显然主要是由于β-胡萝卜素的肠道吸收效率和乳糜微粒代谢的个体间差异。对β-胡萝卜素的反应能力可以影响β-胡萝卜素的状态和β-胡萝卜素的维生素A原活性，但它显然对摄入药理剂量的β-胡萝卜素后血浆中出现的视黄酸量没有影响。
The aim of this study was to assess the interindividual variability of chylomicron beta-carotene response to a pharmacological load of beta-carotene in the population, to identify the mechanisms responsible for this variability, and to evaluate its consequences on beta-carotene status and metabolism. The variability, as estimated by the 3-h chylomicron beta-carotene response to 120 mg beta-carotene in 79 healthy male volunteers, was high (CV = 61%), but it was unimodal and all the subjects had detectable chylomicron beta-carotene. In 16 subjects randomly selected among the 79, the interindividual variability of the triglyceride-adjusted chylomicron (beta-carotene + retinyl palmitate) response (0-12.5 h area under the curve) was high (CV = 54%), suggesting that there is a high interindividual variability in the efficiency of intestinal absorption of beta-carotene. The chylomicron beta-carotene response was correlated (r = 0.50, P < 0.05) with the chylomicron triglyceride response. The beta-carotene status, as assessed by beta-carotene concentration in buccal mucosal cells, was correlated (r = 0.73, P < 0.05) with the triglyceride-adjusted chylomicron beta-carotene response, i.e., with the ability to respond to beta-carotene. The triglyceride-adjusted chylomicron retinyl-palmitate response was correlated (r = 0.55, P < 0.05) with the triglyceride-adjusted chylomicron beta-carotene response. Plasma all-trans retinoic acid slightly, but significantly, increased (+40%) 3 h after the beta-carotene load, but this increase was not related to the triglyceride-adjusted beta-carotene response. In conclusion, the ability to respond to beta-carotene is highly variable, but there is probably a very small proportion of true non-responders to pharmacological doses of beta-carotene in the healthy population. This variability is apparently mainly due to interindividual differences in the efficiency of intestinal absorption of beta-carotene and in chylomicron metabolism. The ability to respond to beta-carotene can affect the beta-carotene status and the provitamin A activity of beta-carotene, but it has apparently no effect on the amount of retinoic acid appearing in the plasma after the ingestion of a pharmacological dose of beta-carotene.
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DOI：
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DOI：
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期刊：
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作者：
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通讯作者：
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