Biomimetic delivery of signals for bone tissue engineering.
Biomimetic delivery of signals for bone tissue engineering.
复制标题
骨组织工程信号的仿生传递
DOI：
10.1038/s41413-018-0025-8
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发表时间：
2018
期刊：
影响因子：
12.7
通讯作者：
Ma PX
中科院分区：
文献类型：
--
作者：
Dang M;Saunders L;Niu X;Fan Y;Ma PX
骨组织工程是直接修复骨缺损或组织工程化骨组织用于移植的一种令人兴奋的方法。生物材料在提供模板和细胞外环境以支持再生细胞和促进组织再生方面发挥着关键作用。已经确定了多种信号线索来调节细胞活性、组织发育和愈合过程。许多研究和试验已经显示了组织工程的前景，但骨组织工程研究到临床应用的成功转化受到限制，部分原因是缺乏这些信号的最佳传递系统。因此，生物医学工程师非常积极地开发仿生药物递送系统，其受益于在发育或自然愈合过程中模拟天然细胞外基质的信号分子释放或呈递。工程仿生药物递送系统旨在根据药物的理化性质和特定的生物学机制来提供对信号分子的位置、时间和释放动力学的控制。本文综述了骨组织工程中信号传递的仿生策略，重点是传递系统而不是特定的分子。讨论了骨组织工程仿生给药系统的基本考虑和具体设计策略，并列举了近年来的研究进展，说明了仿生给药系统在骨组织工程中的重要性和潜力。
Bone tissue engineering is an exciting approach to directly repair bone defects or engineer bone tissue for transplantation. Biomaterials play a pivotal role in providing a template and extracellular environment to support regenerative cells and promote tissue regeneration. A variety of signaling cues have been identified to regulate cellular activity, tissue development, and the healing process. Numerous studies and trials have shown the promise of tissue engineering, but successful translations of bone tissue engineering research into clinical applications have been limited, due in part to a lack of optimal delivery systems for these signals. Biomedical engineers are therefore highly motivated to develop biomimetic drug delivery systems, which benefit from mimicking signaling molecule release or presentation by the native extracellular matrix during development or the natural healing process. Engineered biomimetic drug delivery systems aim to provide control over the location, timing, and release kinetics of the signal molecules according to the drug’s physiochemical properties and specific biological mechanisms. This article reviews biomimetic strategies in signaling delivery for bone tissue engineering, with a focus on delivery systems rather than specific molecules. Both fundamental considerations and specific design strategies are discussed with examples of recent research progress, demonstrating the significance and potential of biomimetic delivery systems for bone tissue engineering.
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