Age-related differences in early novelty processing: using PCA to parse the overlapping anterior P2 and N2 components.
Age-related differences in early novelty processing: using PCA to parse the overlapping anterior P2 and N2 components.
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DOI：
10.1016/j.biopsycho.2015.01.002
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发表时间：
2015-02
影响因子：
2.6
通讯作者：
Holcomb, Phillip J.
中科院分区：
文献类型：
--
作者：
Daffner, Kirk R.;Alperin, Brittany R.;Mott, Katherine K.;Tusch, Erich S.;Holcomb, Phillip J.
以前的工作表明，年龄相关的增加前P2和年龄相关的减少前N2在响应新的刺激。主成分分析（PCA）用于确定这些成分之间的反比关系是否是由于它们的时间和空间重叠。PCA揭示了一个早期的前P2，敏感的任务相关性，和一个晚期的前P2，响应新奇，都表现出与年龄相关的幅度增加。代表前N2的PCA因子，对新奇敏感，表现出与年龄相关的振幅降低。晚期P2与N2对小说的反应呈负相关。较大的晚P2振幅小说与更好的行为表现。在前P2和N2的新的刺激可能代表独立的认知操作的年龄相关的变化，与年龄相关的差异。增强的前P2活动（动机显著性的索引增强）可能是前N2活动减少（老年人处理模糊表征的能力降低）的补偿机制。
Previous work demonstrated age-associated increases in the anterior P2 and age-related decreases in the anterior N2 in response to novel stimuli. Principal component analysis (PCA) was used to determine if the inverse relationship between these components was due to their temporal and spatial overlap. PCA revealed an early anterior P2, sensitive to task relevance, and a late anterior P2, responsive to novelty, both exhibiting age-related amplitude increases. A PCA factor representing the anterior N2, sensitive to novelty, exhibited age-related amplitude decreases. The late P2 and N2 to novels inversely correlated. Larger late P2 amplitude to novels was associated with better behavioral performance. Age-related differences in the anterior P2 and N2 to novel stimuli likely represent age-associated changes in independent cognitive operations. Enhanced anterior P2 activity (indexing augmentation in motivational salience) may be a compensatory mechanism for diminished anterior N2 activity (indexing reduced ability of older adults to process ambiguous representations).
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影响因子：
3.2
作者：
Daffner KR;Chong H;Sun X;Tarbi EC;Riis JL;McGinnis SM;Holcomb PJ
通讯作者：
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影响因子：
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