PACAP38 in human models of primary headaches.
PACAP38 in human models of primary headaches.
复制标题
DOI：
10.1186/s10194-017-0821-3
复制
发表时间：
2017-11-23
期刊：
影响因子：
--
通讯作者：
Ashina M
中科院分区：
文献类型：
--
作者：
Ashina H;Guo S;Vollesen ALH;Ashina M
回顾PACAP38在人类原发性头痛模型中的作用，讨论PACAP38诱导偏头痛的可能机制，并概述未来的研究方向。实验研究已经确定PACAP38是一种有效的偏头痛样发作的药理学“触发”分子。这些研究还揭示了在无先兆偏头痛患者中PACAP38偏头痛反应的异质性。此外，脑成像研究结果表明，在PACAP38输注后，偏头痛患者的神经和血管发生了急性和急性间期的变化。人类偏头痛模型揭示了PACAP38在原发性头痛病理生理学中的重要性。这些研究也指出PAC1受体和PACAP38分子本身是药物测试的靶点。未来的研究应寻求了解pacap38诱发偏头痛的机制。一项正在进行的概念验证随机临床试验的结果可能揭示抗pac1受体抗体预防偏头痛的治疗潜力。
To review the role of PACAP38 in human models of primary headaches, discuss possible mechanisms of PACAP38-induced migraine, and outline future directions. Experimental studies have established PACAP38 as a potent pharmacological “trigger” molecule of migraine-like attacks. These studies have also revealed a heterogeneous PACAP38 migraine response in migraine without aura patients. In addition, findings from brain imaging studies have demonstrated neuronal and vascular changes in migraine patients both ictally and interictally after PACAP38 infusion. Human migraine models have shed light on the importance of PACAP38 in the pathophysiology of primary headaches. These studies have also pointed to the PAC1 receptor and the PACAP38 molecule itself as target sites for drug testing. Future research should seek to understand the mechanisms underlying PACAP38-induced migraine. The results from an ongoing proof of concept randomized clinical trial may reveal the therapeutic potential of anti-PAC1 receptor antibodies for migraine prevention.
登录
查看更多内容
影响因子：
4.9
作者：
Chan, Kayi Y.;Baun, Michael;Gupta, Saurabh
通讯作者：
Gupta, Saurabh
影响因子：
5.1
作者：
Christiansen, I;Daugaard, D;Olesen, J
通讯作者：
Olesen, J
影响因子：
4.9
作者：
Bhatt, Deepak K.;Gupta, Saurabh;Jansen-Olesen, Inger
通讯作者：
Jansen-Olesen, Inger
DOI：
10.1186/s10194-017-0811-5
发表时间：
2017-10-10
期刊：
The journal of headache and pain
影响因子：
--
作者：
Benemei S;Cortese F;Labastida-Ramírez A;Marchese F;Pellesi L;Romoli M;Vollesen AL;Lampl C;Ashina M;School of Advanced Studies of the European Headache Federation (EHF-SAS)
通讯作者：
School of Advanced Studies of the European Headache Federation (EHF-SAS)
影响因子：
4.9
作者：
Amin, Faisal Mohammad;Asghar, Mohammad Sohail;Ashina, Messoud
通讯作者：
Ashina, Messoud