Cardiac sympathetic neuroimaging in dementia with lewy bodies.
Cardiac sympathetic neuroimaging in dementia with lewy bodies.
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DOI：
10.1111/j.1552-6569.2010.00526.x
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发表时间：
2012-04
期刊：
影响因子：
--
通讯作者：
Goldstein DS
中科院分区：
文献类型：
--
作者：
Goldstein DS
神经影像学研究人员和管理痴呆症患者的从业者可能会惊讶地发现，心脏成像可以帮助区分路易体疾病和其他神经退行性疾病。在过去的十几年中，出现了非常一致的神经影像学文献，表明心脏去甲肾上腺素能神经支配是帕金森病（PD）、单纯自主神经功能衰竭和路易体痴呆（DLB）的特征，与多系统萎缩（临床上类似PD）和阿尔茨海默病（老年痴呆症的最常见原因）的正常结果相反。尸检神经病理学研究已经普遍证实了这些区别[1]。最近引入匹兹堡化合物B（Pi B）化合物用于淀粉样蛋白成像被视为阿尔茨海默病领域的重大进展[2]。如Treglia和Cason [3]的荟萃分析中所总结，关于DLB中123 I-间碘苄胍（123 I-MIBG）放射成像的文献支持以下观点：心脏交感神经支配成像可提供一种灵敏、特异的方法，通过检测与α-突触核蛋白神经元内沉积相关的儿茶酚胺能去神经支配，将DLB与其他形式的痴呆进行区分诊断。
Researchers in neuroimaging and practitioners who manage patients with dementia may be surprised to learn that imaging of the heart can help distinguish Lewy body disorders from other causes of neurodegeneration. Over the past dozen years, a remarkably consistent neuroimaging literature has emerged indicating that cardiac noradrenergic denervation characterizes Parkinson disease (PD), pure autonomic failure, and dementia with Lewy bodies (DLB), in contrast with usually normal findings in multiple system atrophy, which can resemble PD clinically, and Alzheimer’s disease, the most common cause of dementia in the elderly. Post-mortem neuropathologic studies have generally confirmed these distinctions [1].The recent introduction of the Pittsburgh compound B (PiB) compound for amyloid imaging is seen as a major advance in the area of Alzheimer’s disease [2]. As summarized in the meta-analysis by Treglia and Cason [3], the literature about 123I-metaiodobenzylguanidine (123I-MIBG) scintigraphy in DLB supports the view that imaging of sympathetic innervation of the heart may provide a sensitive, specific means to diagnose DLB differentially from other forms of dementia, by detecting catecholaminergic denervation associated with intraneuronal deposition of alpha-synuclein.
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影响因子：
11.2
作者：
Li, ST;Dendi, R;Goldstein, DS
通讯作者：
Goldstein, DS
影响因子：
4.1
作者：
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影响因子：
9.9
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14.5
作者：
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Takahashi, Hitoshi
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5.8
作者：
Goldstein, David S.;Sharabi, Yehonatan;Eisenhofer, Graeme
通讯作者：
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