Identifying core herbal treatments for children with asthma: implication from a chinese herbal medicine database in taiwan.
Identifying core herbal treatments for children with asthma: implication from a chinese herbal medicine database in taiwan.
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DOI：
10.1155/2013/125943
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发表时间：
2013
期刊：
影响因子：
--
通讯作者：
Chen JL
中科院分区：
文献类型：
--
作者：
Chen HY;Lin YH;Thien PF;Chang SC;Chen YC;Lo SS;Yang SH;Chen JL
哮喘是世界上最常见的过敏性呼吸道疾病之一，给医疗支付带来巨大负担。台湾儿童常用中草药来控制疾病。本研究的目的是利用全国性的哮喘临床数据库，分析用于治疗哮喘儿童的中药处方。使用国家健康保险研究数据库（NHIRD）进行本研究。纳入1997年至2009年6至18岁儿童哮喘诊断的病历。采用关联规则挖掘和社会网络分析方法对中医药单药及其组合的患病率进行分析。最常用的方剂为麻杏甘石汤（20.2%），其次为小青龙汤（13.1%）和杏苏散（12.8%）。浙贝母是最常用的单味药（SH）（14.6%），其次是杏仁（10.7%）。MXGST常与浙贝母（3.5%）等祛痰类单味药合用。此外，MXGST是缓解哮喘的核心配方。根据本研究的结果，对哮喘常用中药的有效性和安全性还需进一步研究。
Asthma is one of the most common allergic respiratory diseases around the world and places great burden on medical payment. Chinese herbal medicine (CHM) is commonly used for Taiwanese children to control diseases. The aim of this study is to analyze the CHM prescriptions for asthmatic children by using a nationwide clinical database. The National Health Insurance Research Database (NHIRD) was used to perform this study. Medical records from 1997 to 2009 with diagnosis with asthma made for children aged 6 to 18 were included into the analysis. Association rule mining and social network analysis were used to analyze the prevalence of single CHM and its combinations. Ma-Xing-Gan-Shi-Tang (MXGST) was the most commonly used herbal formula (HF) (20.2% of all prescriptions), followed by Xiao-Qing-Long-Tang (13.1%) and Xing-Su-San (12.8%). Zhe Bei Mu is the most frequently used single herb (SH) (14.6%), followed by Xing Ren (10.7%). MXGST was commonly used with Zhe Bei Mu (3.5%) and other single herbs capable of dispelling phlegm. Besides, MXGST was the core formula to relieve asthma. Further studies about efficacy and drug safety are needed for the CHM commonly used for asthma based on the result of this study.
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影响因子：
3.3
作者：
Do, Jeong-Su;Hwang, Jin-Ki;Nam, Sang-Yun
通讯作者：
Nam, Sang-Yun
影响因子：
5.2
作者：
Gaier, Sonja;Marsh, Justin;Shewry, Peter R.
通讯作者：
Shewry, Peter R.
影响因子：
5.4
作者：
Hsieh, Chung-Fan;Lo, Cheng-wei;Horng, Jim-Tong
通讯作者：
Horng, Jim-Tong
影响因子：
5.4
作者：
Kim, Hyun-Ji;Lee, Hai Ja;Park, Eun-Jung
通讯作者：
Park, Eun-Jung
影响因子：
8
作者：
Akinbami, Lara J.;Moorman, Jeanne E.;Sondik, Edward J.
通讯作者：
Sondik, Edward J.