A matrix metalloproteinase mediates airway remodeling in Drosophila.
A matrix metalloproteinase mediates airway remodeling in Drosophila.
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DOI：
10.1016/j.ydbio.2010.05.504
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发表时间：
2010-08-15
影响因子：
2.7
通讯作者：
Page-McCaw A
中科院分区：
文献类型：
--
作者：
Glasheen BM;Robbins RM;Piette C;Beitel GJ;Page-McCaw A
在幼鱼的生长过程中，器官的大小通常会急剧增加。这种生长呈现出一种基本的张力，因为器官需要弹性来抵抗压力，同时仍然保持可塑性以适应生长。细胞外基质（ECM）是提供弹性的核心，但人们对ECM如何改造以适应生长知之甚少。我们研究了果蝇呼吸管（气管）在幼虫生长过程中不断延长的重塑，尽管它们有坚硬的表皮ECM。角质层最初以重复的脊和谷的特征模式沉积，称为带绦虫。我们发现，为了使试管延长，细胞外蛋白酶Mmp1是在每次脱皮期间在带片脊之间扩展ECM所必需的。Mmp1蛋白定位于周期性间隔的小点，这些小点与带轴间距一致。Mmp1还能降解蜕皮时的旧角质层，促进幼虫气管的顶膜扩张，并促进胚胎气管的管伸长。尽管在其他发育系统中的研究表明，MMPs是局部生长区域发生轴向伸长所必需的，但本研究表明，MMPs也可以在器官系统生长过程中介导间质基质重塑。
Organ size typically increases dramatically during juvenile growth. This growth presents a fundamental tension, as organs need resiliency to resist stresses while still maintaining plasticity to accommodate growth. Extracellular matrix (ECM) is central to providing resiliency, but how ECM is remodeled to accommodate growth is poorly understood. We investigated remodeling of Drosophila respiratory tubes (tracheae) that elongate continually during larval growth, despite being lined with a rigid cuticular ECM. Cuticle is initially deposited with a characteristic pattern of repeating ridges and valleys known as taenidia. We find that for tubes to elongate, the extracellular protease Mmp1 is required for expansion of ECM between the taenidial ridges during each inter-molt period. Mmp1 protein localizes in periodically-spaced puncta that are in register with the taenidial spacing. Mmp1 also degrades old cuticle at molts, promotes apical membrane expansion in larval tracheae, and promotes tube elongation in embryonic tracheae. Whereas work in other developmental systems has demonstrated that MMPs are required for axial elongation occurring in localized growth zones, this study demonstrates that MMPs can also mediate interstitial matrix remodeling during growth of an organ system.
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影响因子：
10.5
作者：
Lu, Xin;Wang, Qiongqing;Kang, Yibin
通讯作者：
Kang, Yibin
影响因子：
21.3
作者：
Jazwinska, A;Ribeiro, C;Affolter, M
通讯作者：
Affolter, M
影响因子：
2.7
作者：
Andrew, Deborah J.;Ewald, Andrew J.
通讯作者：
Ewald, Andrew J.
MT2-MMP 依赖性 IV 型胶原 NC1 结构域的释放调节颌下腺分支形态发生。
影响因子：
11.8
作者：
Rebustini, Ivan T.;Myers, Christopher;Lassiter, Keyonica S.;Surmak, Andrew;Szabova, Ludmila;Holmbeck, Kenn;Pedchenko, Vadim;Hudson, Billy G.;Hoffman, Matthew P.
通讯作者：
Hoffman, Matthew P.
影响因子：
4
作者：
Bökel, C;Prokop, A;Brown, NH
通讯作者：
Brown, NH