Morphogenesis of epithelial tubes: Insights into tube formation, elongation, and elaboration.
Morphogenesis of epithelial tubes: Insights into tube formation, elongation, and elaboration.
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DOI：
10.1016/j.ydbio.2009.09.024
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发表时间：
2010-05-01
影响因子：
2.7
通讯作者：
Ewald, Andrew J.
中科院分区：
文献类型：
--
作者：
Andrew, Deborah J.;Ewald, Andrew J.
关键词：
上皮管是后生动物门的基本组织，并提供许多主要器官的基本功能成分。最近在苍蝇和哺乳动物中的工作已经开始阐明在发育过程中驱动上皮管的形成、伸长和分支形态发生的细胞机制。正向和反向遗传技术已经开始确定这些过程的关键分子调节剂，并揭示了关键途径在调节管状网络的生长和发育中的保守作用。在这篇综述中，我们讨论了驱动分支上皮网络形成的发育程序，特别强调果蝇的气管和唾液腺以及哺乳动物的肺、乳腺、肾和唾液腺。我们都强调了这些器官发育的相似性，并试图确定组织和生物体的特定策略。最后，我们简要地考虑如何我们的理解的调节增殖，apico-basal极性，上皮细胞的运动性在分支形态发生过程中可以应用到了解这些相同的过程中的病理失调转移性癌症的进展。
Epithelial tubes are a fundamental tissue across the metazoan phyla and provide an essential functional component of many of the major organs. Recent work in flies and mammals has begun to elucidate the cellular mechanisms driving the formation, elongation and branching morphogenesis of epithelial tubes during development. Both forward and reverse genetic techniques have begun to identify critical molecular regulators for these processes and have revealed the conserved role of key pathways in regulating the growth and elaboration of tubular networks. In this review, we discuss the developmental programs driving the formation of branched epithelial networks, with specific emphasis on the trachea and salivary gland of Drosophila melanogaster and the mammalian lung, mammary gland, kidney, and salivary gland. We both highlight similarities in the development of these organs and attempt to identify tissue and organism specific strategies. Finally, we briefly consider how our understanding of the regulation of proliferation, apico-basal polarity, and epithelial motility during branching morphogenesis can be applied to understand the pathologic dysregulation of these same processes during metastatic cancer progression.
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影响因子：
11.8
作者：
Carroll, TJ;Park, JS;McMahon, AP
通讯作者：
McMahon, AP
影响因子：
2.7
作者：
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通讯作者：
Affolter, Markus
影响因子：
11.8
作者：
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通讯作者：
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影响因子：
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作者：
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通讯作者：
Davis, GE
DOI：
10.1098/rstb.2000.0628
发表时间：
2000-07-29
期刊：
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY OF LONDON SERIES B-BIOLOGICAL SCIENCES
影响因子：
--
作者：
Ainsworth, C;Wan, S;Skaer, H
通讯作者：
Skaer, H