Pattern Formation in the Basilar Papilla: Evidence for Cell Rearrangement
Pattern Formation in the Basilar Papilla: Evidence for Cell Rearrangement
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基底乳头的模式形成：细胞重排的证据
DOI：
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发表时间：
1997
影响因子：
5.3
通讯作者：
G. Richardson
中科院分区：
文献类型：
--
作者：
R. Goodyear;G. Richardson
鸟类的基底乳头由毛和支持细胞组成，它们排列成规则的图案，其中毛细胞被支持细胞突起包围并彼此分离。这种毛细胞顶端边缘不相互接触的细胞排列可能是由接触介导的侧抑制产生的。然而，人们对毛发和支持细胞在发育过程中的组织方式知之甚少。因此，使用针对275 kDa毛细胞抗原和紧密连接蛋白扣带蛋白的抗体进行双标记的完整样品来检查基底乳头中细胞模式的发育。毛细胞在其顶端边缘相互接触，在早期发育过程中，特别是在胚胎日（E）8和9，但E12后不再观察到。在E9和E12时，在乳头的三个不同区域中分析毛发和支持细胞模式。在E9和E12之间的这些区域中的两个中，支持细胞与毛细胞的比率没有显著变化，而每个毛细胞周围的支持细胞的数量和每个支持细胞接触的毛细胞的数量都增加。在检查的第三个区域中，每个毛细胞周围的支持细胞的数量急剧增加，尽管伴随着支持细胞与毛细胞的比例的小而显著的增加，但不能通过支持细胞数量的增加来解释。这些数据表明，毛发和支持细胞相对于彼此的重新排列可能是基底乳头中规则图案发展的基本过程。
The avian basilar papilla is composed of hair and supporting cells arranged in a regular pattern in which the hair cells are surrounded and isolated from each other by supporting cell processes. This arrangement of cells, in which the apical borders of hair cells do not contact one another, may be generated by contact-mediated lateral inhibition. Little is known, however, about the way in which hair and supporting cells are organized during development. Whole mounts double-labeled with antibodies to the 275 kDa hair-cell antigen and the tight junction protein cingulin were therefore used to examine the development of cell patterns in the basilar papilla. Hair cells that contact each other at their apical borders are seen during early development, especially on embryonic days (E) 8 and 9, but are no longer observed after E12. Hair and supporting cell patterns were analyzed in three different areas of the papilla at E9 and E12. In two of these regions between E9 and E12, the ratio of supporting cells to hair cells does not change significantly, whereas there is an increase in both the number of supporting cells around each hair cell and the number of hair cells that each supporting cell contacts. In the third region examined, there is a dramatic rise in the number of supporting cells around each hair cell, which although accompanied by a small, significant increase in the ratio of supporting cells to hair cells cannot be accounted for by an increase in supporting cell numbers. These data show that a rearrangement of hair and supporting cells with respect to one another may be a fundamental process underlying the development of a regular pattern in the basilar papilla.
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胚胎诱导过程中细胞粘附分子的表达。
影响因子：
2.7
作者：
Richardson,GP;Crossin,KL;Chuong,CM;Edelman,GM
通讯作者：
Edelman,GM
影响因子：
2.7
作者：
CAGAN, RL;READY, DF
通讯作者：
READY, DF
神经源性和原神经性基因控制果蝇内胚层中的细胞命运规范。
DOI：
10.1242/dev.121.2.393
发表时间：
1995
期刊：
Development (Cambridge, England)
影响因子：
--
作者：
Tepass,U;Hartenstein,V
通讯作者：
Hartenstein,V
影响因子：
16.2
作者：
DORSKY, RI;RAPAPORT, DH;HARRIS, WA
通讯作者：
HARRIS, WA