Identification of TRPM2 as a Marker Associated With Prognosis and Immune Infiltration in Kidney Renal Clear Cell Carcinoma.
Identification of TRPM2 as a Marker Associated With Prognosis and Immune Infiltration in Kidney Renal Clear Cell Carcinoma.
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TRPM2 鉴定为与肾透明细胞癌预后和免疫浸润相关的标志物
DOI：
10.3389/fmolb.2021.774905
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发表时间：
2021
影响因子：
5
通讯作者：
Tang WH
中科院分区：
文献类型：
--
作者：
Sun L;Zhang Z;Zhao H;Qiu M;Wen Y;Yao X;Tang WH
TRPM 2（瞬时受体电位melastatin-2）是一种Ca 2+可渗透的非选择性阳离子通道，在癌症中高度表达并调节肿瘤细胞的迁移、侵袭和增殖。然而，目前还没有研究表明TRPM 2与癌症患者的预后或肿瘤免疫浸润的相关性，TRPM 2作为癌症预后标志物的可能性和临床基础尚不清楚。在目前的研究中，我们首先探索了TRPM 2的mRNA水平与公共数据库中不同癌症患者预后之间的相关性。随后，使用肿瘤免疫评估资源（TIMER）平台和TISIDB网站评估TRPM 2与肿瘤免疫细胞浸润水平之间的相关性。我们发现1）TRPM 2在大多数肿瘤组织中的水平相对于正常组织显著升高; 2）TRPM 2上调与肾透明细胞癌（KIRC）患者的不良临床特征和不良生存率显著相关; 3）TRPM 2水平与免疫细胞浸润呈正相关。此外，TRPM 2与多种免疫细胞的基因标志物密切相关; 4）基于不同富集的免疫细胞群组，TRPM 2高表达预测KIRC中的较差预后;以及5）TRPM 2主要在T细胞活化过程中实施，所述T细胞活化过程由基因本体（GO）功能和京都基因和基因组百科全书（KEGG）途径富集分析指示。结论TRPM 2可通过调节T细胞活化来预测KIRC的预后和免疫浸润。目前的数据可能为进一步研究TRPM 2在KIRC中的功能提供额外的信息。
TRPM2 (transient receptor potential melastatin-2), a Ca2+ permeable, non-selective cation channel, is highly expressed in cancers and regulates tumor cell migration, invasion, and proliferation. However, no study has yet demonstrated the association of TRPM2 with the prognosis of cancer patients or tumor immune infiltration, and the possibility and the clinical basis of TRPM2 as a prognostic marker in cancers are yet unknown. In the current study, we first explored the correlation between the mRNA level of TRPM2 and the prognosis of patients with different cancers across public databases. Subsequently, the Tumor Immune Estimation Resource (TIMER) platform and the TISIDB website were used to assess the correlation between TRPM2 and tumor immune cell infiltration level. We found that 1) the level of TRPM2 was significantly elevated in most tumor tissues relative to normal tissues; 2) TRPM2 upregulation was significantly associated with adverse clinical characteristics and poor survival of kidney renal clear cell carcinoma (KIRC) patients; 3) the level of TRPM2 was positively related to immune cell infiltration. Moreover, TRPM2 was closely correlated to the gene markers of diverse immune cells; 4) a high TRPM2 expression predicted worse prognosis in KIRC based on different enriched immune cell cohorts; and 5) TRPM2 was mainly implemented in the T-cell activation process indicated by Gene Ontology (GO) function and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis. In conclusion, TRPM2 can serve as a marker to predict the prognosis and immune infiltration in KIRC through the regulation of T-cell activation. The current data may provide additional information for further studies surrounding the function of TRPM2 in KIRC.
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影响因子：
20.1
作者：
Ambale-Venkatesh B;Yang X;Wu CO;Liu K;Hundley WG;McClelland R;Gomes AS;Folsom AR;Shea S;Guallar E;Bluemke DA;Lima JAC
通讯作者：
Lima JAC
GEPIA：用于癌症和正常基因表达谱和交互式分析的网络服务器。
影响因子：
14.9
作者：
Tang Z;Li C;Kang B;Gao G;Li C;Zhang Z
通讯作者：
Zhang Z
影响因子：
8.2
作者：
Belrose JC;Jackson MF
通讯作者：
Jackson MF
影响因子：
82.9
作者：
Binnewies M;Roberts EW;Kersten K;Chan V;Fearon DF;Merad M;Coussens LM;Gabrilovich DI;Ostrand-Rosenberg S;Hedrick CC;Vonderheide RH;Pittet MJ;Jain RK;Zou W;Howcroft TK;Woodhouse EC;Weinberg RA;Krummel MF
通讯作者：
Krummel MF
影响因子：
12.3
作者：
Li B;Severson E;Pignon JC;Zhao H;Li T;Novak J;Jiang P;Shen H;Aster JC;Rodig S;Signoretti S;Liu JS;Liu XS
通讯作者：
Liu XS