A critical role for long-term potentiation mechanisms in the maintenance of object recognition memory in perirhinal cortex revealed by the infusion of zeta inhibitory pseudosubstrate.
A critical role for long-term potentiation mechanisms in the maintenance of object recognition memory in perirhinal cortex revealed by the infusion of zeta inhibitory pseudosubstrate.
复制标题
DOI：
10.3389/fnbeh.2022.970291
复制
发表时间：
2022
影响因子：
3
通讯作者：
中科院分区：
文献类型：
--
作者：
物体识别，即区分新奇刺激和熟悉刺激的能力，严重依赖于嗅周皮层。神经反应减少的重复刺激，已被假设是机制内的周围皮层支持识别记忆功能。因此，对嗅周皮层长期抑制（LTP）机制的研究有助于了解物体识别记忆形成的机制，但长期增强（LTP）对物体识别记忆形成的贡献研究较少。Zeta抑制性假底物（ZIP）对非典型PKC活性的抑制会损害LTP的维持，但不会损害LTD，因此在这里，将ZIP注入周围皮层使我们能够研究LTP样机制对物体识别记忆维持的贡献。样品期24 h后，将ZIP注入大鼠的鼻周皮层，可使大鼠在物体识别任务中表现受损，但在物体定位任务中无损伤；反之，将ZIP注入海马，可使大鼠在物体定位任务中表现受损，但在物体识别任务中无损伤。通过给予肽GluA23y可以阻止含有AMPA受体的GluA2的内吞作用，从而防止ZIP对物体识别的损害。最后，在需要周围皮层功能的感知怪异任务中的表现没有受到ZIP的干扰。综上所述，这些结果证明了ltp样机制对维持周围皮层中物体识别记忆的重要性。
Object recognition, the ability to discriminate between a novel and a familiar stimulus, is critically dependent upon the perirhinal cortex. Neural response reductions upon repetition of a stimulus, have been hypothesized to be the mechanism within perirhinal cortex that supports recognition memory function. Thus, investigations into the mechanisms of long-term depression (LTD) in perirhinal cortex has provided insight into the mechanism of object recognition memory formation, but the contribution of long-term potentiation (LTP) to object recognition memory formation has been less studied. Inhibition of atypical PKC activity by Zeta Inhibitory Pseudosubstrate (ZIP) impairs the maintenance of LTP but not LTD, thus here infusion of ZIP into the perirhinal cortex allowed us to investigate the contribution of LTP-like mechanisms to object recognition memory maintenance. Infusion of ZIP into the perirhinal cortex of rats 24 h after the sample phase impaired performance in an object recognition but not an object location task, in contrast infusion of ZIP into the hippocampus impaired performance in an object location but not an object recognition task. The impairment in object recognition by ZIP was prevented by administration of the peptide GluA23y, which blocks the endocytosis of GluA2 containing AMPA receptors. Finally, performance in a perceptual oddity task, which requires perirhinal cortex function, was not disrupted by ZIP. Together these results demonstrate the importance of LTP-like mechanisms to the maintenance of object recognition memory in the perirhinal cortex.
登录
查看更多内容
影响因子：
3.5
作者：
Norman, Kenneth A.
通讯作者：
Norman, Kenneth A.
影响因子：
3.5
作者：
Evuarherhe, Obaro;Barker, Gareth R. I.;Savalli, Giorgia;Warburton, Elizabeth C.;Brown, Malcolm W.
通讯作者：
Brown, Malcolm W.
影响因子：
4.7
作者：
Panaccione I;King R;Molinaro G;Riozzi B;Battaglia G;Nicoletti F;Bashir ZI
通讯作者：
Bashir ZI
影响因子：
3.7
作者：
von Kraus LM;Sacktor TC;Francis JT
通讯作者：
Francis JT
影响因子：
5.3
作者：
Bartko, Susan J.;Winters, Boyer D.;Bussey, Timothy J.
通讯作者：
Bussey, Timothy J.