Early memory formation disrupted by atypical PKC inhibitor ZIP in the medial prefrontal cortex but not hippocampus.
Early memory formation disrupted by atypical PKC inhibitor ZIP in the medial prefrontal cortex but not hippocampus.
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DOI：
10.1002/hipo.22281
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发表时间：
2014-08
期刊：
影响因子：
3.5
通讯作者：
Brown, Malcolm W.
中科院分区：
文献类型：
--
作者：
Evuarherhe, Obaro;Barker, Gareth R. I.;Savalli, Giorgia;Warburton, Elizabeth C.;Brown, Malcolm W.
蛋白激酶C（aPKC;特别是蛋白激酶M ζ：PKM β）的非典型亚型已被假设为通过GluR 2亚基维持突触后AMPA受体来维持长时程增强（LTP）和长时程记忆所必需和充分的。豆蔻酰化的PKM β假底物肽（ZIP）阻断PKM β活性。本研究探讨了大鼠内侧前额叶皮层（mPFC）和海马ZIP在早期记忆形成和记忆维持中的作用。海马或mPFC中的ZIP输注损害了记忆维持。然而，早期记忆形成受损的ZIP在mPFC，但不海马和阻断GluR 2依赖的AMPA受体的清除并没有影响这种损害所造成的ZIP在mPFC。调查结果表明：（i）海马和内侧前额叶皮层中ZIP作用的差异;（ii）记忆形成早期mPFC中ZIP（可能是PKCλ）的GluR 2非依赖性靶点。
Atypical isoforms of protein kinase C (aPKCs; particularly protein kinase M zeta: PKMζ) have been hypothesised to be necessary and sufficient for the maintenance of long-term potentiation (LTP) and long term memory by maintaining postsynaptic AMPA receptors via the GluR2 subunit. A myristoylated PKMζ pseudosubstrate peptide (ZIP) blocks PKMζ activity. We examined the actions of ZIP in medial prefrontal cortex (mPFC) and hippocampus in associative recognition memory in rats during early memory formation and memory maintenance. ZIP infusion in either hippocampus or mPFC impaired memory maintenance. However, early memory formation was impaired by ZIP in mPFC but not hippocampus; and blocking GluR2-dependent removal of AMPA receptors did not affect this impairment caused by ZIP in the mPFC. The findings indicate: (i) a difference in the actions of ZIP in hippocampus and medial prefrontal cortex, and (ii) a GluR2-independent target of ZIP (possibly PKCλ) in the mPFC during early memory formation.
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影响因子：
9.8
作者：
Serrano, Peter;Friedman, Eugenia L.;Kenney, Jana;Taubenfeld, Stephen M.;Zimmerman, Joshua M.;Hanna, John;Alberini, Cristina;Kelley, Ann E.;Maren, Stephen;Rudy, Jerry W.;Yin, Jerry C. P.;Sacktor, Todd C.;Fenton, Andre A.
通讯作者：
Fenton, Andre A.
影响因子：
2.7
作者：
Dix, SL;Aggleton, JP
通讯作者：
Aggleton, JP
DOI：
10.1073/pnas.1008200107
发表时间：
2010-09-21
影响因子：
11.1
作者：
Ge, Yuan;Dong, Zhifang;Wang, Yu Tian
通讯作者：
Wang, Yu Tian
影响因子：
2.7
作者：
ENNACEUR, A;DELACOUR, J
通讯作者：
DELACOUR, J
DOI：
10.1016/j.molbrainres.2004.05.009
发表时间：
2004-08-23
期刊：
MOLECULAR BRAIN RESEARCH
影响因子：
--
作者：
Oster, H;Eichele, G;Leitges, M
通讯作者：
Leitges, M