Organochlorine pesticides and risk of endometriosis: findings from a population-based case-control study.
Organochlorine pesticides and risk of endometriosis: findings from a population-based case-control study.
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DOI：
10.1289/ehp.1306648
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发表时间：
2013-11
影响因子：
10.4
通讯作者：
Holt VL
中科院分区：
文献类型：
--
作者：
Upson K;De Roos AJ;Thompson ML;Sathyanarayana S;Scholes D;Barr DB;Holt VL
背景：子宫内膜异位症被认为是一种雌激素依赖性疾病。表现出激素特性的持久性环境化学物质，如有机氯农药（OCPs），可能会影响子宫内膜异位症的风险。目的：探讨子宫内膜异位症的风险与环境暴露于OCPs的关系。方法：我们使用来自妇女子宫内膜异位症风险研究（WREN）的数据进行了当前的分析，这是一项基于人群的子宫内膜异位症病例对照研究，在华盛顿州西部一个大型医疗保健系统的18至49岁女性参与者中进行。在1996年至2001年间首次诊断的经手术证实的子宫内膜异位症患者（248例）和基于人群的对照组（538例）的血清中测量了OCP浓度。我们使用无条件逻辑回归估计优势比（OR）和95% ci，调整年龄、参考日期、年份、血脂、教育程度、种族/民族、吸烟和饮酒。结果：我们的数据表明，子宫内膜异位症的风险增加与血清中β-六氯环己烷（HCH）的浓度有关（第三与最低四分位数：OR = 1.7; 95% CI: 1.0, 2.8；最高与最低四分位数OR = 1.3; 95% CI: 0.8, 2.4）和米雷克斯（最高与最低类别：OR = 1.5; 95% CI: 1.0, 2.2）。血清β-HCH浓度与子宫内膜异位症之间的相关性在限制卵巢子宫内膜异位症的分析中更强（第三与最低四分位数：OR = 2.5; 95% CI: 1.5, 5.2；最高与最低四分位数：OR = 2.5; 95% CI: 1.1, 5.3）。结论：在我们的病例对照研究中，在美国太平洋西北地区的一个大型医疗保健系统中登记的妇女，血清中β-HCH和mirex的浓度与子宫内膜异位症正相关。美国过去广泛使用环境持久性氯代农药或其他国家目前使用氯代农药可能影响育龄妇女的健康。引用本文：Upson K， De Roos AJ, Thompson ML, Sathyanarayana S, Scholes D, Barr DB, Holt VL。2013. 有机氯农药与子宫内膜异位症的风险：一项基于人群的病例对照研究的结果环境健康展望121:1319-1324；http://dx.doi.org/10.1289/ehp.1306648
Background: Endometriosis is considered an estrogen-dependent disease. Persistent environmental chemicals that exhibit hormonal properties, such as organochlorine pesticides (OCPs), may affect endometriosis risk. Objective: We investigated endometriosis risk in relation to environmental exposure to OCPs. Methods: We conducted the present analyses using data from the Women’s Risk of Endometriosis (WREN) study, a population-based case–control study of endometriosis conducted among 18- to 49-year-old female enrollees of a large health care system in western Washington State. OCP concentrations were measured in sera from surgically confirmed endometriosis cases (n = 248) first diagnosed between 1996 and 2001 and from population-based controls (n = 538). We estimated odds ratios (OR) and 95% CIs using unconditional logistic regression, adjusting for age, reference date year, serum lipids, education, race/ethnicity, smoking, and alcohol intake. Results: Our data suggested increased endometriosis risk associated with serum concentrations of β-hexachlorocyclohexane (HCH) (third vs. lowest quartile: OR = 1.7; 95% CI: 1.0, 2.8; highest vs. lowest quartile OR = 1.3; 95% CI: 0.8, 2.4) and mirex (highest vs. lowest category: OR = 1.5; 95% CI: 1.0, 2.2). The association between serum β-HCH concentrations and endometriosis was stronger in analyses restricting cases to those with ovarian endometriosis (third vs. lowest quartile: OR = 2.5; 95% CI: 1.5, 5.2; highest vs. lowest quartile: OR = 2.5; 95% CI: 1.1, 5.3). Conclusions: In our case–control study of women enrolled in a large health care system in the U.S. Pacific Northwest, serum concentrations of β-HCH and mirex were positively associated with endometriosis. Extensive past use of environmentally persistent OCPs in the United States or present use in other countries may affect the health of reproductive-age women. Citation: Upson K, De Roos AJ, Thompson ML, Sathyanarayana S, Scholes D, Barr DB, Holt VL. 2013. Organochlorine pesticides and risk of endometriosis: findings from a population-based case–control study. Environ Health Perspect 121:1319–1324; http://dx.doi.org/10.1289/ehp.1306648
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影响因子：
10.4
作者：
Lubin JH;Colt JS;Camann D;Davis S;Cerhan JR;Severson RK;Bernstein L;Hartge P
通讯作者：
Hartge P
DOI：
10.1016/s0889-8545(05)70302-8
发表时间：
1997-06-01
影响因子：
3.2
作者：
Eskenazi, B;Warner, ML
通讯作者：
Warner, ML
DOI：
10.1016/j.reprotox.2010.05.011
发表时间：
2010-11
期刊：
Reproductive toxicology (Elmsford, N.Y.)
影响因子：
--
作者：
Cooney MA;Buck Louis GM;Hediger ML;Vexler A;Kostyniak PJ
通讯作者：
Kostyniak PJ
DOI：
10.1002/jbt.2570100303
发表时间：
1995-06-01
期刊：
JOURNAL OF BIOCHEMICAL TOXICOLOGY
影响因子：
--
作者：
FOSTER, WG;MERTINEIT, C;LECAVALIER, P
通讯作者：
LECAVALIER, P
DOI：
10.1056/nejmcp1000274
发表时间：
2010-06-24
期刊：
The New England journal of medicine
影响因子：
--
作者：
Giudice LC
通讯作者：
Giudice LC