Age-related changes in muscle architecture and metabolism in humans: The likely contribution of physical inactivity to age-related functional decline.
Age-related changes in muscle architecture and metabolism in humans: The likely contribution of physical inactivity to age-related functional decline.
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DOI：
10.1016/j.arr.2021.101344
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发表时间：
2021-07
影响因子：
13.1
通讯作者：
Greenhaff PL
中科院分区：
文献类型：
--
作者：
Shur NF;Creedon L;Skirrow S;Atherton PJ;MacDonald IA;Lund J;Greenhaff PL
衰老与肌肉质量、质量和胰岛素敏感性的下降有关。这些衰老的特征在缺乏体育活动的年轻人身上迅速显现。失活驱动的肌肉失调的细胞机制尚不清楚。不活动对肌肉随年龄下降的确切贡献尚不清楚。由生活方式因素引起的肌肉老化至少可以部分逆转。在联合王国，预计到2035年，65岁以上的人将占总人口的23%，85岁以上的人将占总人口的5%。衰老与肌肉代谢的渐进性变化和功能能力的下降有关，导致独立性的丧失。与衰老相关的肌肉代谢变化与肌肉结构的改变以及肌肉质量和胰岛素敏感性的下降有关。然而，通常归因于肌肉老化的生物学特征也出现在对身体不活动的对照研究中（例如步数减少和卧床休息），目前尚不清楚这些老化特征中有多少是由于老化本身或久坐不动。在新型冠状病毒肺炎（COVID-19）大流行期间，居家隔离降低了身体活动水平，这一点尤其重要。目前的知识差距包括身体不活动在与老年肌肉衰退相关的许多负面特征的发展中所起的相对作用。同样，政府推荐的身体活动指南对肌肉健康的积极影响的数据基本上是不存在的。因此，必须优先研究衰老，身体活动和肌肉质量与代谢健康之间的相互作用，以便它可以为“正常”肌肉衰老过程以及改善健康寿命和福祉的策略提供信息。这篇综述将集中在肌肉结构和新陈代谢的重要变化，伴随着衰老，并强调了身体不活动对这些变化的可能贡献。
Ageing is associated with declines in muscle mass, quality and insulin sensitivity. These features of ageing quickly manifest in young exposed to physical inactivity. The cellular mechanisms of inactivity-driven muscle dysregulation are unclear. The precise contribution of inactivity to muscle decline with age is unknown. Muscle ageing caused by lifestyle factors may be at least partly reversible. In the United Kingdom (UK), it is projected that by 2035 people aged >65 years will make up 23 % of the population, with those aged >85 years accounting for 5% of the total population. Ageing is associated with progressive changes in muscle metabolism and a decline in functional capacity, leading to a loss of independence. Muscle metabolic changes associated with ageing have been linked to alterations in muscle architecture and declines in muscle mass and insulin sensitivity. However, the biological features often attributed to muscle ageing are also seen in controlled studies of physical inactivity (e.g. reduced step-count and bed-rest), and it is currently unclear how many of these ageing features are due to ageing per se or sedentarism. This is particularly relevant at a time of home confinements reducing physical activity levels during the Covid-19 pandemic. Current knowledge gaps include the relative contribution that physical inactivity plays in the development of many of the negative features associated with muscle decline in older age. Similarly, data demonstrating positive effects of government recommended physical activity guidelines on muscle health are largely non-existent. It is imperative therefore that research examining interactions between ageing, physical activity and muscle mass and metabolic health is prioritised so that it can inform on the “normal” muscle ageing process and on strategies for improving health span and well-being. This review will focus on important changes in muscle architecture and metabolism that accompany ageing and highlight the likely contribution of physical inactivity to these changes.
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DOI：
10.1016/j.metabol.2009.09.014
发表时间：
2010-05
期刊：
Metabolism: clinical and experimental
影响因子：
--
作者：
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DOI：
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发表时间：
2016-12-15
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影响因子：
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作者：
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Atherton PJ
影响因子：
15.9
作者：
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DOI：
10.1016/j.bbalip.2017.07.010
发表时间：
2017-10-01
影响因子：
4.8
作者：
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