Rapid T1 mapping of mouse myocardium with saturation recovery Look-Locker method.
Rapid T1 mapping of mouse myocardium with saturation recovery Look-Locker method.
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DOI：
10.1002/mrm.22544
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发表时间：
2010-11
影响因子：
3.3
通讯作者：
Yu X
中科院分区：
文献类型：
--
作者：
Li W;Griswold M;Yu X
动态对比增强MRI （DCE-MRI）使用钆或锰提供心肌及其病理的独特表征。在目前的研究中，开发了一种ecg触发饱和恢复Look-Locker （SRLL）方法，并在小动物模型中验证了该方法的快速心脏T1定位。通过对纵向磁化恢复曲线的初始部分采样，可以在小鼠心脏的高空间分辨率（195×390µm2）下获得高时间分辨率（~3 min），而无需平行成像或EPI。验证研究分别在体外幻体和体内C57BL/6小鼠（n=6）上进行。我们的研究结果表明，SRLL测量的T1与体外标准饱和恢复方法或体内倒置恢复Look-Locker方法测量的T1有很强的一致性。在小鼠锰增强MRI实验中证实了SRLL在DEC-MRI研究中的应用。我们的研究结果表明，SRLL可以为利用小动物模型的研究提供快速准确的心脏T1制图。
Dynamic contrast enhanced MRI (DCE-MRI) using gadolinium or manganese provides unique characterization of myocardium and its pathology. In the current study, an ECG-triggered saturation recovery Look-Locker (SRLL) method was developed and validated for fast cardiac T1 mapping in small animal models. By sampling the initial portion of the longitudinal magnetization recovery curve, high temporal resolution (~3 min) can be achieved at a high spatial resolution (195×390 µm2) in mouse heart without the aid of parallel imaging or EPI. Validation studies were performed both in vitro on a phantom and in vivo on C57BL/6 mice (n=6). Our results showed a strong agreement between T1 measured by SRLL and by the standard saturation recovery method in vitro or inversion recovery Look-Locker in vivo. The utility of SRLL in DEC-MRI studies was demonstrated in manganese-enhanced MRI experiments in mice. Our results suggest that SRLL can provide rapid and accurate cardiac T1 mapping for studies utilizing small animal models.
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