Review of Constituents and Biological Activities of Triterpene Saponins from Glycyrrhizae Radix et Rhizoma and Its Solubilization Characteristics.
Review of Constituents and Biological Activities of Triterpene Saponins from Glycyrrhizae Radix et Rhizoma and Its Solubilization Characteristics.
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DOI：
10.3390/molecules25173904
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发表时间：
2020-08-27
期刊：
影响因子：
--
通讯作者：
Lei H
中科院分区：
文献类型：
--
作者：
Li F;Liu B;Li T;Wu Q;Xu Z;Gu Y;Li W;Wang P;Ma T;Lei H
黄芪被认为是最受欢迎和最常用的草药之一，并已被用于传统中药（TCM）处方超过2000年。五环三萜皂苷是这些植物中常见的次生代谢产物，其通过类异戊二烯途径合成以产生含有亲水性糖链的疏水性三萜苷元。本文系统总结了黄芪中三萜皂苷类化合物的化学结构，并对其主要生物活性研究进行了综述和更新。并对黄芪的增溶特性、增溶效果及增溶机理进行了阐述。黄芪三萜皂苷类化合物的增溶作用是由于其含有非极性皂苷元和水溶性侧链。影响黄芪增溶的可能因素主要是其他药材和水煎液的pH值。三萜皂苷类化合物具有两亲性，可形成胶束，使增溶成为可能。为更好地了解黄芪及其中药配伍提供了指导，也为黄芪的进一步开发利用提供了理论依据。
Glycyrrhizae Radix et Rhizoma is regarded as one of the most popular and commonly used herbal medicines and has been used in traditional Chinese medicine (TCM) prescriptions for over 2000 years. Pentacyclic triterpene saponins are common secondary metabolites in these plants, which are synthesized via the isoprenoid pathway to produce a hydrophobic triterpenoid aglycone containing a hydrophilic sugar chain. This paper systematically summarizes the chemical structures of triterpene saponins in Glycyrrhizae Radix et Rhizoma and reviews and updates their main biological activities studies. Furthermore, the solubilization characteristics, influences, and mechanisms of Glycyrrhizae Radix et Rhizoma are elaborated. Solubilization of the triterpene saponins from Glycyrrhizae Radix et Rhizoma occurs because they contain the nonpolar sapogenin and water-soluble sidechain. The possible factors affecting the solubilization of Glycyrrhizae Radix et Rhizoma are mainly other crude drugs and the pH of the decoction. Triterpene saponins represented by glycyrrhizin from Glycyrrhizae Radix et Rhizoma characteristically form micelles due to amphiphilicity, which makes solubilization possible. This overview provides guidance regarding a better understanding of Glycyrrhizae Radix et Rhizoma and its TCM compatibility, alongside a theoretical basis for the further development and utilization of Glycyrrhizae Radix et Rhizoma.
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影响因子：
7.6
作者：
BABA, M;SHIGETA, S
通讯作者：
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作者：
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影响因子：
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作者：
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影响因子：
5.9
作者：
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