Gut microbiota: Role in pathogen colonization, immune responses, and inflammatory disease.
Gut microbiota: Role in pathogen colonization, immune responses, and inflammatory disease.
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DOI：
10.1111/imr.12567
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发表时间：
2017-09
影响因子：
8.7
通讯作者：
Núñez G
中科院分区：
文献类型：
--
作者：
Pickard JM;Zeng MY;Caruso R;Núñez G
哺乳动物的肠道被大量微生物定殖，包括统称为肠道微生物群的数万亿细菌。这些土著微生物与宿主以共生关系共同进化。除了代谢益处之外，共生细菌还为宿主提供促进免疫稳态、免疫应答和防止病原体定植的若干功能。共生细菌抑制病原体定殖的能力是通过几种机制介导的，包括直接杀死、竞争有限的营养物质和增强免疫应答。病原体已经进化出在肠道微生物群存在下促进其复制的策略。环境和遗传因素对肠道微生物群结构的干扰增加了病原体感染的风险，促进了有害致病菌的过度生长和炎症性疾病的发展。了解微生物群与病原体和免疫系统的相互作用将为疾病的发病机制以及预防和治疗炎症性疾病的策略的制定提供重要的见解。
The intestinal tract of mammals is colonized by a large number of microorganisms including trillions of bacteria that are referred to collectively as the gut microbiota. These indigenous microorganisms have co-evolved with the host in a symbiotic relationship. In addition to metabolic benefits, symbiotic bacteria provide the host with several functions that promote immune homeostasis, immune responses and protection against pathogen colonization. The ability of symbiotic bacteria to inhibit pathogen colonization is mediated via several mechanisms including direct killing, competition for limited nutrients and enhancement of immune responses. Pathogens have evolved strategies to promote their replication in the presence of the gut microbiota. Perturbation of the gut microbiota structure by environmental and genetic factors increases the risk of pathogen infection, promotes the overgrowth of harmful pathobionts, and the development of inflammatory disease. Understanding the interaction of the microbiota with pathogens and the immune system will provide critical insight into the pathogenesis of disease and the development of strategies to prevent and treat inflammatory disease.
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影响因子：
6.7
作者：
Bergstrom KS;Kissoon-Singh V;Gibson DL;Ma C;Montero M;Sham HP;Ryz N;Huang T;Velcich A;Finlay BB;Chadee K;Vallance BA
通讯作者：
Vallance BA
影响因子：
30.3
作者：
Cahenzli J;Köller Y;Wyss M;Geuking MB;McCoy KD
通讯作者：
McCoy KD
影响因子：
30.3
作者：
Burberry A;Zeng MY;Ding L;Wicks I;Inohara N;Morrison SJ;Núñez G
通讯作者：
Núñez G
影响因子：
82.9
作者：
通讯作者：
--
小鼠肠道对实验沙门氏菌感染的抗性。 I.干扰口服接种感染的因素。
影响因子：
15.3
作者：
BOHNHOFF, M;MILLER, C P;MARTIN, W R
通讯作者：
MARTIN, W R