Bursting as a source of non-linear determinism in the firing patterns of nigral dopamine neurons.
Bursting as a source of non-linear determinism in the firing patterns of nigral dopamine neurons.
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DOI：
10.1111/j.1460-9568.2012.08238.x
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发表时间：
2012-11
期刊：
影响因子：
--
通讯作者：
Peterson BS
中科院分区：
文献类型：
--
作者：
Jeong J;Shi WX;Hoffman R;Oh J;Gore JC;Bunney BS;Peterson BS
黑质多巴胺（DA）神经元在体内表现出复杂的放电模式，包括紧张性单棘波和相位爆发，编码某些类型的奖励相关的学习和行为的信息。非线性动力学分析先前已经证明了DA神经元的复杂放电模式中存在非线性确定性结构，但这种非线性确定性的起源仍然未知。在这项研究中，我们假设，爆发活动是DA神经元放电模式的非线性决定论的主要来源。为了验证这一假设，我们研究了在体内记录的放电间隔数据的维度复杂性，从水合氯醛麻醉的大鼠黑质的爆发和非爆发DA神经元。我们发现，爆发性DA神经元的放电模式表现出非线性确定性，而非爆发性DA神经元则表现出真正的随机放电模式。从爆发神经元的放电模式中提取的孤立爆发和爆发间间隔数据中也检测到了确定性。此外，在氟烷麻醉的大鼠较少的DA神经元爆裂表现出更高的维度尖峰动力学比水合氯醛麻醉的大鼠更多的DA神经元爆裂。这些结果有力地表明，爆发活动是低维，非线性决定论的DA神经元的放电模式的主要来源。这一发现进一步表明，爆发可能是有意义的信息在DA神经元的放电活动的载体。
Nigral dopamine (DA) neurons in vivo exhibit complex firing patterns consisting of tonic single-spikes and phasic bursts that encode information for certain types of reward-related learning and behavior. Non-linear dynamical analysis has previously demonstrated the presence of a non-linear deterministic structure in complex firing patterns of DA neurons, yet the origin of this non-linear determinism remains unknown. In this study, we hypothesized that bursting activity is the primary source of non-linear determinism in the firing patterns of DA neurons. To test this hypothesis, we investigated the dimension complexity of inter-spike interval data recorded in vivo from bursting and non-bursting DA neurons in the chloral hydrate-anesthetized rat substantia nigra. We found that bursting DA neurons exhibited non-linear determinism in their firing patterns, whereas non-bursting DA neurons showed truly stochastic firing patterns. Determinism was also detected in the isolated burst and inter-burst interval data extracted from firing patterns of bursting neurons. Moreover, less bursting DA neurons in halothane-anesthetized rats exhibited higher dimensional spiking dynamics than do more bursting DA neurons in chloral hydrate-anesthetized rats. These results strongly indicate that bursting activity is the main source of low-dimensional, non-linear determinism in the firing patterns of DA neurons. This finding furthermore suggests that bursts are the likely carriers of meaningful information in the firing activities of DA neurons.
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