Elevated basal luteinizing hormone does not impair the outcome of human menopausal gonadotropin and medroxyprogesterone acetate treatment cycles.
Elevated basal luteinizing hormone does not impair the outcome of human menopausal gonadotropin and medroxyprogesterone acetate treatment cycles.
复制标题
基础黄体生成激素升高不会损害人类绝经期促性腺激素和醋酸甲羟孕酮治疗周期的结果
DOI：
10.1038/s41598-018-32128-4
复制
发表时间：
2018-09-14
影响因子：
4.6
通讯作者：
Kuang Y
中科院分区：
文献类型：
--
作者：
Sun L;Ye J;Wang Y;Chen Q;Cai R;Fu Y;Tian H;Lyu Q;Lu X;Kuang Y
高基础促黄体生成激素（LH）水平对人类生殖的潜在影响存在争议。为了证明基础LH水平升高对接受体外受精/卵胞浆内单精子注射（IVF/ICSI）周期患者结局的影响，我们对2013年11月至2017年6月在我中心接受人绝经期促性腺激素和醋酸甲羟孕酮（hMG + MPA）方案治疗的1011例多囊卵巢综合征（PCOS）患者进行了回顾性数据分析。基础LH水平升高的PCOS患者在刺激期间LH暴露量显著升高。LH ≥ 10 mIU/mL的组显示使用的平均总hMG剂量较低，但获得的卵母细胞、中期II卵母细胞、胚胎和优质胚胎的数量高于基础LH水平较低的组。此外，偏相关分析显示，基础LH水平与总hMG剂量呈负相关，但与获卵数、中期II卵母细胞数、胚胎数和优质胚胎数呈正相关。冷冻胚胎移植组的取卵率、受精率、种植率、临床妊娠率和流产率差异无统计学意义。我们的结论是，基础LH水平升高不会影响PCOS妇女接受hMG + MPA治疗的IVF/ICSI周期的最终结局。
The potential effects of high basal luteinizing hormone (LH) levels on human reproduction were controversial. To demonstrate the effects of elevated basal LH levels on the outcome of patients undergoingin vitrofertilization/intracytoplasmic sperm injection (IVF/ICSI) cycles, we performed a retrospective data analysis of 1011 polycystic ovarian syndrome (PCOS) patients treated with human menopausal gonadotropin and medroxyprogesterone acetate (hMG + MPA) protocol at our center between Nov. 2013 and Jun. 2017. PCOS patients with elevated basal LH levels had significantly higher LH exposure during the stimulation period. The group with LH ≥ 10 mIU/mL showed a lower mean total hMG dose used but higher numbers of oocytes retrieved, metaphase II oocytes, embryos and top-quality embryos developed than the groups with lower basal LH levels. Moreover, partial correlation analysis showed that the basal LH level was negatively correlated with the total hMG dose but positively correlated with the numbers of oocytes retrieved, metaphase II oocytes, embryos, and top-quality embryos. There were no significant differences in the rates of oocyte retrieval, fertilization, implantation, clinical pregnancy and miscarriage between the groups based on frozen embryo transfer (FET). We concluded that elevated basal LH level does not impair the final outcome of hMG + MPA-treated IVF/ICSI cycles in PCOS women.
登录
查看更多内容
影响因子：
6.1
作者：
Kolibianakis, EM;Papanikolaou, EG;Devroey, P
通讯作者：
Devroey, P
影响因子：
6.1
作者：
Fauser, BCJM;Chang, J;Lobo, R
通讯作者：
Lobo, R
影响因子：
6.7
作者：
Westergaard, LG;Erb, K;Rasmussen, PE
通讯作者：
Rasmussen, PE
DOI：
10.1016/j.bpobgyn.2004.06.001
发表时间：
2004-10-01
影响因子：
5.5
作者：
van der Spuy, ZM;Dyer, SJ
通讯作者：
Dyer, SJ
影响因子：
6.1
作者：
Huirne, JAF;van Loenen, ACD;Lambalk, CB
通讯作者：
Lambalk, CB