Increased miR-449a expression in colorectal carcinoma tissues is inversely correlated with serum carcinoembryonic antigen.
Increased miR-449a expression in colorectal carcinoma tissues is inversely correlated with serum carcinoembryonic antigen.
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DOI：
10.3892/ol.2013.1737
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发表时间：
2014-02
期刊：
影响因子：
2.9
通讯作者：
Zhang Y
中科院分区：
文献类型：
--
作者：
Chen S;Dai Y;Zhang X;Jin D;Li X;Zhang Y
此前，microRNA-449 a（miR-449 a）已被证明与各种类型的癌症有关。然而，其在结直肠癌中的作用仍然未知。本研究发现，与正常结直肠细胞和癌旁非肿瘤组织相比，miR-449 a在培养的结直肠癌细胞和24例结直肠癌患者的癌组织中的表达显著增加。癌组织中miR-449 a的表达与血清癌胚抗原（CEA）水平呈负相关（R2=0.88）。miR-449 a的表达增加出现在表现出正常血清CEA水平（<5 ng/ml）的患者中，但不出现在CEA水平升高（>5 ng/ml）的患者中。miR-449 a表达在TNM早期（II期）增加，在III期和IV期没有显着变化。提示miR-449 a参与了大肠癌的发生发展，可能是一个潜在的预后指标。
Previously, microRNA-449a (miR-449a) has been shown to be involved in various types of cancer. However, its role in colorectal carcinoma remains unknown. The present study found that miR-449a expression was significantly increased in cultured colorectal carcinoma cells and cancer tissues obtained from 24 patients diagnosed with colorectal carcinoma, compared with the normal colorectal cells and the adjacent non-tumor tissues. The miR-449a expression in carcinoma tissues revealed an inverse correlation with the levels of serum carcinoembryonic antigen (CEA; R2=0.88). The increased expression of miR-449a appeared in the patients who exhibited normal serum levels of CEA (<5 ng/ml), but not in those with elevated CEA levels (>5 ng/ml). miR-449a expression increased at an early TNM stage (stage II) and did not change significantly at stages III and IV. These results suggested that miR-449a is involved in the development of colorectal carcinoma and may be a potential prognosis indicator.
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影响因子：
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作者：
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通讯作者：
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影响因子：
3.7
作者：
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影响因子：
9.7
作者：
Chen, Hong;Lin, Yi-Wei;Xie, Li-Ping
通讯作者：
Xie, Li-Ping