Characterizing regulatory path motifs in integrated networks using perturbational data.
Characterizing regulatory path motifs in integrated networks using perturbational data.
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DOI：
10.1186/gb-2010-11-3-r32
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发表时间：
2010
期刊：
影响因子：
12.3
通讯作者：
Michoel T
中科院分区：
文献类型：
--
作者：
Joshi A;Van Parys T;Van de Peer Y;Michoel T
Pathular – 推出了一个用于分析细胞对转录因子扰动的反应的 Cytoscape 插件 我们介绍了 Pathically http://bioinformatics.psb.ugent.be/software/details/Pathular，这是一个 Cytoscape 插件，用于通过将扰动表达数据与转录、蛋白质-蛋白质和磷酸化网络相结合来研究细胞对转录因子扰动的反应。 Pathicular searches for 'regulatory path motifs', short paths in the integrated physical networks which occur significantly more often than expected between transcription factors and their targets in the perturbational data.酿酒酵母的案例研究确定了八个调控路径基序并证明了它们的生物学意义。
Pathicular – a Cytoscape plugin for analysing cellular responses to transcription factor perturbations is presented We introduce Pathicular http://bioinformatics.psb.ugent.be/software/details/Pathicular, a Cytoscape plugin for studying the cellular response to perturbations of transcription factors by integrating perturbational expression data with transcriptional, protein-protein and phosphorylation networks. Pathicular searches for 'regulatory path motifs', short paths in the integrated physical networks which occur significantly more often than expected between transcription factors and their targets in the perturbational data. A case study in Saccharomyces cerevisiae identifies eight regulatory path motifs and demonstrates their biological significance.
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