Impacts of GRIN3A, GRM6 and TPH2 genetic polymorphisms on quality of life in methadone maintenance therapy population.
Impacts of GRIN3A, GRM6 and TPH2 genetic polymorphisms on quality of life in methadone maintenance therapy population.
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DOI：
10.1371/journal.pone.0201408
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发表时间：
2018
期刊：
影响因子：
3.7
通讯作者：
Hung CC
中科院分区：
文献类型：
--
作者：
Wang RY;Chen HJ;Huang CL;Wang JY;Lee TE;Lee HY;Hung CC
阿片类药物成瘾是世界范围内的一个重大公共卫生问题。美沙酮维持治疗（MMT）用于非法阿片类药物使用者的解毒，但药物复发是常见的，并与生活质量（QoL）差有关。本研究探讨了MMT人群中GRIN3A、GRM6和TPH2遗传变异与生活质量之间的关系。该研究共纳入319名参与者，使用Sequenom iPLEX对GRIN3A、GRM6和TPH2基因进行基因分型。采用SAS 9.1.3软件，采用LSMEANS语法对基因型与QoL结构域之间的关系进行事后分析。TPH2基因的单核苷酸多态性rs9325202和rs1487275与生理功能的QoL结构域显著相关。最小绝对收缩和选择算子回归模型显示，当考虑临床特征作为协变量时，风险等位基因rs1487275-G与身体功能域显著相关。本研究结果阐明了MMT人群生活质量遗传基础的重要性，并建议基因型应被视为潜在的生活质量指标。
Opioid addiction is a major public health issue worldwide. Methadone maintenance treatment (MMT) is used to detoxify users of illicit opiates, but drug relapse is common and associated with poor quality of life (QoL). This study investigated the associations between the GRIN3A, GRM6, and TPH2 genetic variants and QoL in the MMT population. A total of 319 participants were included in the study, and genotyping of GRIN3A, GRM6, and TPH2 genes was performed using the Sequenom iPLEX. Associations between genotypes and the domains of QoL were examined through posthoc analysis with LSMEANS syntax using SAS 9.1.3. The single nucleotide polymorphisms rs9325202 and rs1487275 in the TPH2 gene were significantly associated with the QoL domain of physical functioning. The least absolute shrinkage and selection operator regression model revealed that the risk allele rs1487275-G was significantly correlated with the domain of physical functioning when clinical characteristics were considered as covariates. The results of the present study illuminate the importance of the genetic basis of QoL in the MMT population, and suggest that genotypes should be considered as a potential QoL indicator.
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影响因子：
10.6
作者：
Lucki, I
通讯作者：
Lucki, I
DOI：
10.5812/ijhrba.22275
发表时间：
2015-12
影响因子：
--
作者：
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通讯作者：
Khosravi A
影响因子：
4.2
作者：
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通讯作者：
Verthein, U.
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DOI：
10.1016/j.pnpbp.2015.08.003
发表时间：
2016-01-04
影响因子：
5.6
作者：
Levran O;Peles E;Randesi M;Correa da Rosa J;Ott J;Rotrosen J;Adelson M;Kreek MJ
通讯作者：
Kreek MJ
影响因子：
2
作者：
Laudet, Alexandre B.;Becker, Jeffrey B.;White, William L.
通讯作者：
White, William L.