The Internet and clinical trials: background, online resources, examples and issues.
The Internet and clinical trials: background, online resources, examples and issues.
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DOI：
10.2196/jmir.7.1.e5
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发表时间：
2005-03-16
影响因子：
7.4
通讯作者：
Prescott T
中科院分区：
文献类型：
--
作者：
Paul J;Seib R;Prescott T
互联网和临床试验都是20世纪下半叶的重大发展：互联网彻底改变了全球通信，随机对照试验提供了一种对两种或两种以上治疗方法进行公正比较的方法。大型多中心试验通常需要花费大量的开发时间和大量的费用，并且在获取、备份和分析大量数据方面面临重大挑战。随着现代临床试验的日益复杂，互联网在改善通信、集中和保护数据以及分发信息方面的力量也在增强。随着越来越多的临床试验需要实时协调多个试验过程，各中心正在转向互联网作为工具来管理临床试验的组成部分，无论是全部还是部分，以产生更低的成本和更快的结果。本文回顾了互联网和随机对照试验的历史发展，描述了可用于临床试验的互联网资源，回顾了一些在线试验的例子，并描述了使用互联网进行临床试验的优点和缺点。我们还提取了迄今为止使用互联网进行的5项最大的临床试验的特征，这些试验总共招募了26000多名患者。
Both the Internet and clinical trials were significant developments in the latter half of the twentieth century: the Internet revolutionized global communications and the randomized controlled trial provided a means to conduct an unbiased comparison of two or more treatments. Large multicenter trials are often burdened with an extensive development time and considerable expense, as well as significant challenges in obtaining, backing up and analyzing large amounts of data. Alongside the increasing complexities of the modern clinical trial has grown the power of the Internet to improve communications, centralize and secure data as well as to distribute information. As more and more clinical trials are required to coordinate multiple trial processes in real time, centers are turning to the Internet for the tools to manage the components of a clinical trial, either in whole or in part, to produce lower costs and faster results. This paper reviews the historical development of the Internet and the randomized controlled trial, describes the Internet resources available that can be used in a clinical trial, reviews some examples of online trials and describes the advantages and disadvantages of using the Internet to conduct a clinical trial. We also extract the characteristics of the 5 largest clinical trials conducted using the Internet to date, which together enrolled over 26000 patients.
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影响因子：
2.6
作者：
Edworthy, SM
通讯作者：
Edworthy, SM
影响因子：
158.5
作者：
HILL, AB
通讯作者：
HILL, AB
DOI：
10.1016/s0197-2456(00)00070-2
发表时间：
2000-10-01
期刊：
CONTROLLED CLINICAL TRIALS
影响因子：
--
作者：
Brandt, CA;Nadkarni, P;Miller, PL
通讯作者：
Miller, PL
影响因子：
39.2
作者：
Hunt, DL;McKibbon, KA
通讯作者：
McKibbon, KA
影响因子：
7.4
作者：
Formica M;Kabbara K;Clark R;McAlindon T
通讯作者：
McAlindon T