Candida auris: Epidemiology, Diagnosis, Pathogenesis, Antifungal Susceptibility, and Infection Control Measures to Combat the Spread of Infections in Healthcare Facilities.
Candida auris: Epidemiology, Diagnosis, Pathogenesis, Antifungal Susceptibility, and Infection Control Measures to Combat the Spread of Infections in Healthcare Facilities.
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Candida Auris：流行病学，诊断，发病机理，抗真菌敏感性和感染控制措施，以打击医疗机构中感染的传播。
DOI：
10.3390/microorganisms9040807
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发表时间：
2021-04-11
期刊：
影响因子：
4.5
通讯作者：
Alfouzan W
中科院分区：
文献类型：
--
作者：
Ahmad S;Alfouzan W
耳念珠菌（Candida auris）是一种新近发现的具有多重耐药性的酵母菌，由于其在医疗机构中引起侵袭性感染和暴发的能力，已成为一种重要的真菌病原体，难以控制和治疗。耳内寄生虫很容易污染患者周围的环境并长期存在，最近在许多国家导致了大规模疫情。C.耳抵抗通过强力清洁和其它去污程序的消除，这可能是由于“干”生物膜的形成。易感的住院患者，特别是那些在重症监护环境中有多种合并症的患者，获得C。auris与C.耳道感染患者、其环境或用于殖民患者的设备，通常会造成致命的后果。本文着重介绍了近年来有关抗真菌药物耐药的流行病学、诊断、发病机制、易感性和分子基础以及对抗念珠菌传播的感染控制措施等方面的研究成果。医疗机构中的耳部感染。特别强调旨在预防医疗机构新感染的干预措施，包括筛查易感患者的定植;清洁和净化环境，设备和定植患者;以及识别和治疗感染患者的成功方法，特别是在疫情期间。
Candida auris, a recently recognized, often multidrug-resistant yeast, has become a significant fungal pathogen due to its ability to cause invasive infections and outbreaks in healthcare facilities which have been difficult to control and treat. The extraordinary abilities of C. auris to easily contaminate the environment around colonized patients and persist for long periods have recently resulted in major outbreaks in many countries. C. auris resists elimination by robust cleaning and other decontamination procedures, likely due to the formation of ‘dry’ biofilms. Susceptible hospitalized patients, particularly those with multiple comorbidities in intensive care settings, acquire C. auris rather easily from close contact with C. auris-infected patients, their environment, or the equipment used on colonized patients, often with fatal consequences. This review highlights the lessons learned from recent studies on the epidemiology, diagnosis, pathogenesis, susceptibility, and molecular basis of resistance to antifungal drugs and infection control measures to combat the spread of C. auris infections in healthcare facilities. Particular emphasis is given to interventions aiming to prevent new infections in healthcare facilities, including the screening of susceptible patients for colonization; the cleaning and decontamination of the environment, equipment, and colonized patients; and successful approaches to identify and treat infected patients, particularly during outbreaks.
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