Lessons to learn from tumor-educated platelets.
Lessons to learn from tumor-educated platelets.
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DOI：
10.1182/blood.2019003976
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发表时间：
2021-06-10
期刊：
影响因子：
20.3
通讯作者：
Battinelli EM
中科院分区：
文献类型：
--
作者：
Roweth HG;Battinelli EM
长期以来，人们知道血小板在止血和血栓形成之外发挥着重要作用。现在被认为是恶性疾病的真正媒介，血小板影响癌症进展的各个方面，最显著的是肿瘤细胞转移。有趣的是，从癌症患者分离的血小板通常显示不同的RNA和蛋白质谱，在止血活性方面没有明显的变化。这种表型独特的人群，被称为肿瘤教育血小板，现在受到了极大的关注，因为它们可能作为一种现成的液体活检用于早期癌症检测。尽管支持血小板教育的机制仍不明确，但最突出的情况是肿瘤衍生因子的直接摄取和储存，血小板RNA加工中的信号依赖性变化，以及受肿瘤教育的巨核细胞产生不同的血小板。本文旨在介绍肿瘤对血小板教育的各种方式，并对其诊断潜力进行评估。
Platelets have long been known to play important roles beyond hemostasis and thrombosis. Now recognized as a bona fide mediator of malignant disease, platelets influence various aspects of cancer progression, most notably tumor cell metastasis. Interestingly, platelets isolated from cancer patients often display distinct RNA and protein profiles, with no clear alterations in hemostatic activity. This phenotypically distinct population, termed tumor-educated platelets, now receive significant attention for their potential use as a readily available liquid biopsy for early cancer detection. Although the mechanisms underpinning platelet education are still being defined, direct uptake and storage of tumor-derived factors, signal-dependent changes in platelet RNA processing, and differential platelet production by tumor-educated megakaryocytes are the most prominent scenarios. This article aims to cover the various modalities of platelet education by tumors, in addition to assessing their diagnostic potential.
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影响因子：
3.3
作者：
Eicher JD;Wakabayashi Y;Vitseva O;Esa N;Yang Y;Zhu J;Freedman JE;McManus DD;Johnson AD
通讯作者：
Johnson AD
DOI：
10.1111/jth.13302
发表时间：
2016-05
期刊：
Journal of thrombosis and haemostasis : JTH
影响因子：
--
作者：
Bye AP;Unsworth AJ;Gibbins JM
通讯作者：
Gibbins JM
DOI：
10.1073/pnas.61.1.46
发表时间：
1968-01-01
影响因子：
11.1
作者：
GASIC, GJ;GASIC, TB;STEWART, CC
通讯作者：
STEWART, CC
影响因子：
20.3
作者：
Camerer, E;Qazi, AA;Coughlin, SR
通讯作者：
Coughlin, SR
影响因子：
5.9
作者：
Bailey, Sarah E. R.;Ukoumunne, Obioha C.;Hamilton, Willie
通讯作者：
Hamilton, Willie