Expression of the cellular prion protein by mast cells in the human carotid body.
Expression of the cellular prion protein by mast cells in the human carotid body.
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DOI：
10.1080/19336896.2023.2193128
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发表时间：
2023-12
期刊：
影响因子：
2.3
通讯作者：
Kincaid, Anthony E. E.
中科院分区：
文献类型：
--
作者：
Sweetland, Gregory D. D.;Eggleston, Connor;Bartz, Jason C. C.;Mathiason, Candace K. K.;Kincaid, Anthony E. E.
关键词：
朊病毒病是一种致命的神经系统疾病，可以通过输血传播。接触受感染血液后的神经侵袭途径尚不清楚。颈动脉体 (CB) 是专门的化学敏感结构，可检测血气浓度并为呼吸的神经控制提供反馈。 CB 的感觉细胞高度灌注，并受到与脑干和胸脊髓突触连接的神经的密集支配，已知这些神经是口腔感染后早期朊病毒沉积的区域。鉴于它们直接暴露于血液以及与参与朊病毒神经侵袭的中枢神经系统（CNS）区域的神经连接，我们试图确定人类CB中是否存在表达细胞朊病毒蛋白（PrPC）的细胞，这一特征支持CB作为朊病毒神经侵袭的途径。我们从尸体供体中收集了 CB，并确定位于颈动脉体中的肥大细胞表达 PrPC，并且这些细胞非常接近与脑干和脊髓突触连接的血管、神经和神经末梢。
Prion diseases are fatal neurologic disorders that can be transmitted by blood transfusion. The route for neuroinvasion following exposure to infected blood is not known. Carotid bodies (CBs) are specialized chemosensitive structures that detect the concentration of blood gasses and provide feedback for the neural control of respiration. Sensory cells of the CB are highly perfused and densely innervated by nerves that are synaptically connected to the brainstem and thoracic spinal cord, known to be areas of early prion deposition following oral infection. Given their direct exposure to blood and neural connections to central nervous system (CNS) areas involved in prion neuroinvasion, we sought to determine if there were cells in the human CB that express the cellular prion protein (PrPC), a characteristic that would support CBs serving as a route for prion neuroinvasion. We collected CBs from cadaver donor bodies and determined that mast cells located in the carotid bodies express PrPC and that these cells are in close proximity to blood vessels, nerves, and nerve terminals that are synaptically connected to the brainstem and spinal cord.
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DOI：
10.3390/v13112287
发表时间：
2021-11-16
期刊：
Viruses
影响因子：
--
作者：
Kincaid AE
通讯作者：
Kincaid AE
影响因子：
7.3
作者：
Krystel-Whittemore M;Dileepan KN;Wood JG
通讯作者：
Wood JG
影响因子：
5.6
作者：
Otlyga D;Tsvetkova E;Junemann O;Saveliev S
通讯作者：
Saveliev S
影响因子：
3.3
作者：
KUMMER, W;HABECK, JO
通讯作者：
HABECK, JO
影响因子：
168.9
作者：
Llewelyn, CA;Hewitt, PE;Will, RG
通讯作者：
Will, RG