Endothelial SIRT-1 has a critical role in the maintenance of capillarization in brown adipose tissue.
Endothelial SIRT-1 has a critical role in the maintenance of capillarization in brown adipose tissue.
复制标题
DOI：
10.1016/j.isci.2022.105424
复制
发表时间：
2022-11-18
期刊：
影响因子：
5.8
通讯作者：
Minamino, Tohru
中科院分区：
文献类型：
--
作者：
Furuuchi, Ryo;Shimizu, Ippei;Yoshida, Yohko;Katsuumi, Goro;Suda, Masayoshi;Kubota, Yoshiaki;Walsh, Kenneth;Minamino, Tohru
褐色脂肪组织（BAT）在产热和全身代谢中起着关键作用。有报道称，饮食性肥胖的BAT会出现毛细血管稀疏，先前的研究表明，抑制血管内皮生长因子A （VEGF-A）会降低BAT的毛细血管密度，促进该器官的功能下降。毛细血管化是通过血管生成和血管生成与内皮细胞（ECs）凋亡的平衡来调节的；然而，EC凋亡在BAT中的作用仍有待探讨。在测试boysenberry多酚（BoyP）在BAT中的作用的研究中，我们发现BoyP减少EC凋亡，增强BAT的毛细血管化，改善饮食BAT功能障碍，这与EC中烟酰胺腺嘌呤二核苷酸依赖的蛋白去乙酰化酶sirtuin 1 （SIRT-1）的上调有关。我们的研究表明EC SIRT-1可能是BoyP的潜在靶点之一，有助于BAT的毛细血管化和功能。饮食肥胖和热中性降低BAT ECs中SIRT-1的表达，Boysenberry多酚增加EC SIRT-1的表达，EC SIRT-1在BAT中维持毛细血管化具有关键作用；分子生物学;细胞生物学。
Brown adipose tissue (BAT) has critical roles in thermogenesis and systemic metabolism. Capillary rarefaction was reported to develop in BAT with dietary obesity, and previous studies showed that suppression of vascular endothelial growth factor A (VEGF-A) reduced capillary density in BAT, promoting the functional decline of this organ. Capillarization is regulated through the balance between angiogenesis and vasculogenesis on the one hand and apoptosis of endothelial cells (ECs) on the other; however, the role of EC apoptosis in BAT remained to be explored. In studies testing the role of boysenberry polyphenols (BoyP) in BAT, we found that BoyP decreased EC apoptosis, enhanced capillarization in BAT, and ameliorated dietary BAT dysfunction, which was associated with the upregulation of nicotinamide adenine dinucleotide-dependent protein deacetylase sirtuin 1 (SIRT-1) in ECs. Our studies suggest that EC SIRT-1 would be one of the potential targets of BoyP that contributes to BAT capillarization and function. Dietary obesity and thermoneutrality reduce SIRT-1 expression in BAT ECs Boysenberry polyphenols increase EC SIRT-1 expression EC SIRT-1 has a critical role in maintaining capillarization in BAT Biological sciences; Molecular biology; Cell biology.
登录
查看更多内容
DOI：
10.1126/science.1231097
发表时间：
2013-03-08
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Hubbard BP;Gomes AP;Dai H;Li J;Case AW;Considine T;Riera TV;Lee JE;E SY;Lamming DW;Pentelute BL;Schuman ER;Stevens LA;Ling AJ;Armour SM;Michan S;Zhao H;Jiang Y;Sweitzer SM;Blum CA;Disch JS;Ng PY;Howitz KT;Rolo AP;Hamuro Y;Moss J;Perni RB;Ellis JL;Vlasuk GP;Sinclair DA
通讯作者：
Sinclair DA
影响因子：
3.7
作者：
Furuuchi R;Shimizu I;Yoshida Y;Hayashi Y;Ikegami R;Suda M;Katsuumi G;Wakasugi T;Nakao M;Minamino T
通讯作者：
Minamino T
DOI：
10.1152/ajpheart.00281.2014
发表时间：
2014-12-15
影响因子：
4.8
作者：
Maizel, Julien;Xavier, Sandhya;Goligorsky, Michael S.
通讯作者：
Goligorsky, Michael S.
影响因子：
2.5
作者：
Cui X;Nguyen NL;Zarebidaki E;Cao Q;Li F;Zha L;Bartness T;Shi H;Xue B
通讯作者：
Xue B
影响因子：
5.6
作者：
Li, Jing;Zhang, Yingjiang;Yang, Xiaolong
通讯作者：
Yang, Xiaolong