Beneficial effects of extended‐release doxazosin and doxazosin standard on sexual health
Beneficial effects of extended‐release doxazosin and doxazosin standard on sexual health
复制标题
缓释多沙唑嗪和多沙唑嗪标准品对性健康的有益作用
作者：
S. Kaplan;A. F. de Rose;R. Kirby;M. O'Leary;K. McVary
良性前列腺肥大（BPH）和勃起功能障碍（ED）的患病率都随着年龄的增长而增加，越来越多的证据表明这是一个共同的原因，而不是独立的年龄相关变化。动脉高血压常伴随这些泌尿系统疾病，提示α‐肾上腺素能受体活性升高可能是这三种疾病的病因。作为该模型的证据，α -肾上腺素受体拮抗剂，如doxazosin，在降低血压、减少前列腺增生和BPH症状以及缓解ED方面产生有益的治疗效果。在海绵体的结后α1受体处，去甲肾上腺素引起血管平滑肌细胞收缩，限制血液流动，导致阴茎肿胀。就像α‐肾上腺素能拮抗剂导致全身血管松弛以降低血压一样，阴茎中的相同机制调节去甲肾上腺素的作用以促进血管扩张，从而改善勃起功能。越来越多的临床证据证明doxazosin在缓解ED方面的有效性，甚至对ED特异性治疗难治性患者，以及减轻BPH症状和血压升高。
The prevalence of benign prostatic hypertrophy (BPH) and erectile dysfunction (ED) both increase with age, and increasing evidence suggests a common cause rather than independent age‐related changes. Arterial hypertension often accompanies these urological disorders, suggesting the possibility that increased α‐adrenoceptor activity may be causal in all three conditions. As evidence for this model, α‐adrenoceptor antagonists such as doxazosin produce therapeutically beneficial effects in lowering blood pressure, reducing prostate growth and BPH symptoms, and relieving ED. At postjunctional α1‐receptors in the corpus cavernosa, noradrenaline causes vascular smooth muscle cell contraction, restricting blood flow, resulting in penile detumescence. Just as α‐adrenoceptor antagonism results in systemic vasorelaxation to lower blood pressure, the same mechanism in the penis modulates the effects of noradrenaline to favour vasodilatation, resulting in improved erectile function. Increasing clinical evidence attests to the effectiveness of doxazosin in relieving ED, even in patients refractory to ED‐specific treatment, as well as in reducing BPH symptoms and elevated blood pressure.
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