Sleep Duration and Cancer in the NIH-AARP Diet and Health Study Cohort.
Sleep Duration and Cancer in the NIH-AARP Diet and Health Study Cohort.
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NIH-AARP饮食和健康研究队列中的睡眠持续时间和癌症。
DOI：
10.1371/journal.pone.0161561
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发表时间：
2016
期刊：
影响因子：
3.7
通讯作者：
Caporaso NE
中科院分区：
文献类型：
--
作者：
Gu F;Xiao Q;Chu LW;Yu K;Matthews CE;Hsing AW;Caporaso NE
除了乳腺癌之外，很少有研究调查睡眠时间与癌症发病率的关系。我们在NIH-AARP健康与饮食研究队列中评估了睡眠时间与总癌症和18种特定部位癌症发病率之间的关系，基线时年龄在51-72岁之间的173，327名男性和123，858名女性。通过问卷调查评估自我报告的睡眠持续时间类别。我们使用多变量考克斯比例风险回归来估计风险比（HR）和95%置信区间（CI），使用7-8小时/夜作为参考。我们观察到男性短睡眠者患胃癌的风险显著增加（多变量HR 5 -6 vs. 7-8小时= 1.29; 95%CI：1.05，1.59; P趋势= 0.03）。我们还观察到，无论是短睡眠者还是长睡眠者，（P趋势>0.05），包括男性短睡眠者患头颈癌的风险增加（HR<5 vs.7 -8小时= 1.39; 95%CI：1.00-1.95），膀胱（HR 5 - 6 vs.7 -8小时= 1.10; 95%CI：1.00-1.20），甲状腺（HR<5对比7-8小时= 2.30; 95%CI：1.06，5.02）、非霍奇金淋巴瘤（NHL）（HR 5 - 6对比7 -8小时= 1.17; 95%CI：1.02-1.33）和骨髓瘤（HR<5对比7 -8小时= 2.06; 95%CI：1.20-3.51）。在女性中，暗示性的关联包括短睡眠者的总癌症风险降低（HR<5vs.7-8小时= 0.9; 95%CI：0.83-0.99）和乳腺癌风险降低（HR<5vs.7-8小时= 0.84; 95%CI：0.71-0.98）。在长时间睡眠者中观察到卵巢癌风险降低（HR≥ 9 vs. 7-8小时= 0.50; 95%CI：0.26-0.97）和NHL风险增加（HR≥ 9 vs. 7-8小时= 1.45; 95%CI：1.00-2.11）。在老年人群中，我们观察到男性短睡眠者患胃癌的风险增加，并提示男女睡眠时间短或长与许多癌症风险有关。
Very few studies have examined sleep duration in relation to cancer incidence with the exception of breast cancer. We assessed the associations between sleep duration and incidences of total and 18 site-specific cancers in the NIH-AARP Health and Diet Study cohort, with 173,327 men and 123,858 women aged 51–72 years at baseline. Self-reported sleep duration categories were assessed via questionnaire. We used multivariable Cox proportional hazards regression to estimate hazard ratios (HR) and 95% confidence intervals (CI), using 7–8 hours/night as the reference. We observed a significantly increased risk of stomach cancer among male short sleepers (multivariable HR5-6 vs. 7–8 hours = 1.29; 95%CI: 1.05, 1.59; Ptrend = 0.03). We also observed suggestive associations in either short or long sleepers, which did not reach overall significance (Ptrend >0.05), including increased risks in male short sleepers for cancers of head and neck (HR<5vs.7-8 hours = 1.39; 95%CI:1.00–1.95), bladder (HR5-6vs.7-8 hours = 1.10; 95%CI:1.00–1.20), thyroid (HR<5 vs. 7–8 hours = 2.30; 95%CI:1.06, 5.02), Non-Hodgkin Lymphoma (NHL) (HR5-6vs.7-8 hours = 1.17; 95%CI:1.02–1.33), and myeloma (HR<5vs.7-8 hours = 2.06; 95%CI:1.20–3.51). In women, the suggestive associations include a decreased total cancer risk (HR<5vs.7-8 hours = 0.9; 95%CI:0.83–0.99) and breast cancer risk (HR<5vs.7-8 hours = 0.84; 95%CI:0.71–0.98) among short sleepers. A decreased ovarian cancer risk (HR≥ 9 vs. 7–8 hours = 0.50; 95%CI:0.26–0.97) and an increased NHL risk (HR≥ 9 vs. 7–8 hours = 1.45; 95%CI:1.00–2.11) were observed among long sleepers. In an older population, we observed an increased stomach cancer risk in male short sleepers and suggestive associations with short or long sleep duration for many cancer risks in both genders.
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影响因子：
8.8
作者：
Kakizaki, M.;Kuriyama, S.;Sone, T.;Ohmori-Matsuda, K.;Hozawa, A.;Nakaya, N.;Fukudo, S.;Tsuji, I.
通讯作者：
Tsuji, I.
影响因子：
8.8
作者：
Jiao, L.;Duan, Z.;Sangi-Haghpeykar, H.;Hale, L.;White, D. L.;El-Serag, H. B.
通讯作者：
El-Serag, H. B.
影响因子：
8.8
作者：
Kakizaki, M.;Inoue, K.;Kuriyama, S.;Sone, T.;Matsuda-Ohmori, K.;Nakaya, N.;Fukudo, S.;Tsuji, I.
通讯作者：
Tsuji, I.
影响因子：
16.2
作者：
Cappuccio FP;D'Elia L;Strazzullo P;Miller MA
通讯作者：
Miller MA
影响因子：
4.4
作者：
Monk TH;Buysse DJ;Billy BD;Fletcher ME;Kennedy KS;Begley AE;Schlarb JE;Beach SR
通讯作者：
Beach SR