Body mass index, waist-to-hip ratio and late outcomes: a report from the Shanghai Breast Cancer Survival Study.
Body mass index, waist-to-hip ratio and late outcomes: a report from the Shanghai Breast Cancer Survival Study.
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体重指数、腰臀比和晚期结果：上海乳腺癌生存研究报告
DOI：
10.1038/s41598-017-07320-7
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发表时间：
2017-08-01
影响因子：
4.6
通讯作者：
Zheng Y
中科院分区：
文献类型：
--
作者：
Zhang M;Cai H;Bao P;Xu W;Qin G;Shu XO;Zheng Y
肥胖与乳腺癌生存率的关系已经得到了很好的研究。然而，诊断后肥胖和晚期结局（诊断后≥5年）的相关性研究要少得多。上海乳腺癌生存研究共招募了4062例5年无病患者，这是一项对2002-2006年诊断的患者进行的纵向研究。采用限制性三次样条考克斯比例风险模型分析诊断后体重指数（BMI）和腰臀比（WHR）与晚期全因死亡率和晚期复发的潜在非线性关系。虽然未观察到诊断后BMI或WHR与晚期复发的显著相关性，但观察到这两项指标与晚期全因死亡的U形相关性。BMI为25.0 kg/m2或WHR为0.83的女性晚期全因死亡风险最低，而BMI超过22.1-28.7 kg/m2或WHR超过0.81-0.86的女性风险较高。ER、分期或绝经状态并不能改变诊断后BMI或WHR对结局的影响。总之，诊断后BMI和WHR分别作为整体和中心性肥胖的指标，与长期乳腺癌幸存者的晚期全因死亡率呈U型相关。
Obesity has been well studied in relation to breast cancer survival. However, the associations of post-diagnosis obesity and late outcomes (≥5 years after diagnosis) have been much less studied. A total of 4062 5-year disease-free patients were recruited from the Shanghai Breast Cancer Survival Study, a longitudinal study of patients diagnosed during 2002-2006. Cox proportional hazard model with restricted cubic spline were used to evaluate the potential non-linear associations of post-diagnosis body mass index (BMI) and waist-to-hip ratio (WHR) with late all-cause mortality and late recurrence. While no significant association was observed for post-diagnosis BMI or WHR with late recurrence; a U-shaped association was observed for the two measures with late all-cause death. Women with BMI of 25.0 kg/m2 or WHR of 0.83 were at the lowest risk of late all-cause mortality, whereas those with BMI beyond the range of 22.1–28.7 kg/m2 or WHR beyond the range of 0.81–0.86 had a higher risk. ER, stage or menopausal status did not modify the effect of post-diagnosis BMI or WHR on the outcomes. In conclusion, post-diagnosis BMI and WHR, as indicators of overall and central obesity respectively, were associated with late all-cause mortality in U-shaped pattern among long-term breast cancer survivors.
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影响因子：
8.8
作者：
Bandera EV;Lee VS;Qin B;Rodriguez-Rodriguez L;Powell CB;Kushi LH
通讯作者：
Kushi LH
影响因子：
2
作者：
DURRLEMAN, S;SIMON, R
通讯作者：
SIMON, R
影响因子：
3.8
作者：
Kwan, Marilyn L.;Chen, Wendy Y.;Kroenke, Candyce H.;Weltzien, Erin K.;Beasley, Jeannette M.;Nechuta, Sarah J.;Poole, Elizabeth M.;Lu, Wei;Holmes, Michelle D.;Quesenberry, Charles P., Jr.;Pierce, John P.;Shu, Xiao Ou;Caan, Bette J.
通讯作者：
Caan, Bette J.
影响因子：
4
作者：
Bellera CA;MacGrogan G;Debled M;de Lara CT;Brouste V;Mathoulin-Pélissier S
通讯作者：
Mathoulin-Pélissier S
影响因子：
6.4
作者：
Dal Maso, Luigino;Zucchetto, Antonella;Franceschi, Silvia
通讯作者：
Franceschi, Silvia