ApoE rs429358 and rs7412 Polymorphism and Gender Differences of Serum Lipid Profile and Cognition in Aging Chinese Population.
ApoE rs429358 and rs7412 Polymorphism and Gender Differences of Serum Lipid Profile and Cognition in Aging Chinese Population.
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中国老龄化人群ApoE rs429358和rs7412多态性及血脂谱和认知的性别差异
DOI：
10.3389/fnagi.2017.00248
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发表时间：
2017
影响因子：
4.8
通讯作者：
Yuan L
中科院分区：
文献类型：
--
作者：
Zhen J;Huang X;Van Halm-Lutterodt N;Dong S;Ma W;Xiao R;Yuan L
载脂蛋白E基因多态性与血脂和认知功能有关。然而，在中国人群中，很少有研究探讨载脂蛋白E基因多态性和性别对血脂水平的联合影响以及随后对认知的影响。在这项横断面研究中，共招募了1000名55岁及以上的中国社区居民。参与者的人口统计信息是使用精心设计的自我管理问卷收集的。采用蒙特利尔认知评估(MoCA)测验评估受试者的认知状态。采用半定量食物频率问卷(FFQ)获取膳食摄入量信息。取空腹静脉血进行载脂蛋白E基因分型和血脂检测。在认知、血脂谱和膳食高脂肪食物摄入量方面存在显著的性别差异(p<；0.05)。研究人员发现受试者的认知与ApoE基因型别有关(p<；0.05)。APOE rs429358和rs7412变异分别对男性受试者的认知表现有显著影响，特别是在注意力和语言认知领域以及MoCA总分(p<；0.05)。中国成年人的血脂谱和认知功能与性别和载脂蛋白E基因多态性显著相关。ApoE变异rs429358与中国老年男性人群的认知功能显著相关。
ApoE gene polymorphism has been reportedly associated with serum lipids and cognition. However, very few studies have explored the combined effects of ApoE gene polymorphism and gender on serum lipid profile with subsequent impacts on cognition in Chinese population. A total of 1,000 Chinese community dwellers aged 55 years and above were recruited in this cross-sectional study. Demographic information of the participants was collected using well designed self-administered questionnaires. The Montreal Cognitive Assessment (MoCA) test was employed to evaluate the cognitive status of the participants. Semi-quantitative food frequency questionnaire (FFQ) was used to obtain the dietary intake information. Fasting venous blood samples were taken for ApoE genotyping and serum lipid measurements. Significant gender differences in cognition, serum lipid profile and dietary fat-rich foods consumption were observed (p < 0.05). Cognition of the subjects was found to be associated with ApoE genotypes (p < 0.05). ApoE rs429358 and rs7412 variants demonstrated a significant effect on cognitive performance in the male subjects; especially within the attention and language cognitive domains as well as the total MoCA score (p < 0.05), respectively. Serum lipid profile and cognition of Chinese adults are significantly linked with gender and ApoE genetic polymorphism. The ApoE variant rs429358 is found to be notably associated with cognition in aging male Chinese population.
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DOI：
10.3233/jad-2010-100864
发表时间：
2010
期刊：
Journal of Alzheimer's disease : JAD
影响因子：
--
作者：
Bennet AM;Reynolds CA;Gatz M;Blennow K;Pedersen NL;Prince JA
通讯作者：
Prince JA
影响因子：
5.3
作者：
Gómez-Coronado, D;Alvarez, JJ;Lasunción, MA
通讯作者：
Lasunción, MA
影响因子：
1.9
作者：
Ghobadzadeh, Maryam;Demerath, Ellen W.;Tura, Yisehak
通讯作者：
Tura, Yisehak
影响因子：
9.9
作者：
Fratiglioni, L;Viitanen, M;Winblad, B
通讯作者：
Winblad, B
DOI：
10.1111/j.1532-5415.1999.tb07427.x
发表时间：
1999-11-01
影响因子：
6.3
作者：
Barrett-Connor, E;Goodman-Gruen, D
通讯作者：
Goodman-Gruen, D