Preoperative leukocytosis is associated with increased tumor-infiltrating neutrophil extracellular traps and worse outcomes in esophageal cancer
Preoperative leukocytosis is associated with increased tumor-infiltrating neutrophil extracellular traps and worse outcomes in esophageal cancer
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术前白细胞增多与肿瘤浸润中性粒细胞胞外陷阱增加和食管癌预后较差相关
DOI：
10.21037/atm.2020.03.190
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发表时间：
2020-04
影响因子：
--
通讯作者：
Miao Changhong
中科院分区：
文献类型：
--
作者：
Zhang Hao;Lv Hu;Wen Meilin;Wang Huihui;Cata Juan P.;Chen Wankun;Miao Changhong
背景：我们评价了食道癌手术患者术前白细胞计数与预后的关系，并探讨了术前白细胞计数与肿瘤浸润性中性粒细胞细胞外陷阱(NETs)的关系。方法：选择2013年1月至2017年12月复旦大学上海肿瘤中心(FUSCC)收治的3096例食管癌手术患者为研究对象。探讨术前WBC计数与肿瘤浸润性NETs联合检测的预后价值。结果：白细胞增多(P=10,000/亩L)与总生存期(OS)和无病生存期(DFS)显著相关(P=7,000/亩L)也是影响生存的独立预后因素。此外，中度白细胞增多与男性(P=0.006)、晚期T分期(P<；0.001)、TNM分期(P<；0.001)和术后化疗无效(P<；0.001)相关，中度白细胞增高甚至预示术后复发增加(P<；0.001)。重要的是，中度白细胞增多症患者肿瘤内NETS的浸润率显著升高(P<；0.001)，且NETs浸润率越高，OS和DFS越差(P<；0.001)。结论：我们的数据表明，术前中度白细胞增多症与肿瘤浸润性网络的增加有关，并且是食管癌术后生存的一个独立的预后因素。
Background: We evaluated the correlation between preoperative white blood cell (WBC) count and the prognosis in esophageal cancer (EC) patients who underwent esophagectomy, and explored the potential link between preoperative WBC count and tumor-infiltrating neutrophil extracellular traps (NETs) in EC. Methods: From January 2013 to December 2017, 3,096 patients at Fudan University Shanghai Cancer Center (FUSCC) undergoing esophagectomy for EC were enrolled in this retrospective cohort. The prognostic value of preoperative WBC count together with tumor-infiltrating NETs was investigated. Results: Leukocytosis (>= 10,000/mu L) was significantly associated with decreased overall survival (OS) and disease-free survival (DFS) (P= 7,000/mu L) were also identified as an independent prognostic factor for survival. Additionally, moderate leukocytosis was correlated with male sex (P=0.006), advanced T stage (P<0.001), TNM stage (P<0.001) and ineffective postoperative chemotherapy (P<0.001), and moderate leukocytosis even predicted increased relapse postoperatively (P<0.001). Importantly, patients with moderate leukocytosis had a significantly higher level of intra-tumoral NETs infiltration (P<0.001), and the higher level of NETs infiltration were associated with worse OS and DFS (P<0.001). Conclusions: Our data indicated that preoperative moderate leukocytosis is associated with increased tumor-infiltrating NETs and is an independent prognostic factor for survival in EC after surgery.
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DOI：
10.1126/science.aao4227
发表时间：
2018-09-28
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Albrengues J;Shields MA;Ng D;Park CG;Ambrico A;Poindexter ME;Upadhyay P;Uyeminami DL;Pommier A;Küttner V;Bružas E;Maiorino L;Bautista C;Carmona EM;Gimotty PA;Fearon DT;Chang K;Lyons SK;Pinkerton KE;Trotman LC;Goldberg MS;Yeh JT;Egeblad M
通讯作者：
Egeblad M
影响因子：
8
作者：
通讯作者：
--
影响因子：
4.7
作者：
M. Worley;C. Nitschmann;M. Shoni;A. Vitonis;J. Rauh-Hain;C. Feltmate
通讯作者：
M. Worley;C. Nitschmann;M. Shoni;A. Vitonis;J. Rauh-Hain;C. Feltmate
影响因子：
5.2
作者：
de Nonneville, Alexandre;Barbolosi, Dominique;Salas, Sebastien
通讯作者：
Salas, Sebastien
影响因子：
4
作者：
Rosales C
通讯作者：
Rosales C